Severe combined immunodeficiency
MONDO:0015974Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.
Also known as: SCID, severe combined immunodeficiency, severe combined immunodeficiency (disease), severe combined immunodeficiency disease
38 clinical trials for this condition and its sub-types, 24 tagged with Severe combined immunodeficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Severe combined immunodeficiency
-
Familial severe combined immunodeficiency 0 trials · 22 incl. sub-types
14 sub-types
- T-B+ severe combined immunodeficiency due to gamma chain deficiency 10 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency 6 trials
- Omenn syndrome 4 trials
- Severe combined immunodeficiency due to DCLRE1C deficiency 3 trials
- T-B+ severe combined immunodeficiency due to JAK3 deficiency 2 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive 2 trials
- MHC class II deficiency 1 trial Sub-types →
- Reticular dysgenesis 1 trial Sub-types →
- Cernunnos-XLF deficiency 0 trials
- Immunodeficiency 104 0 trials
- Immunodeficiency 105 0 trials
- Immunodeficiency 18 0 trials
- Immunodeficiency 19 0 trials
- Immunodeficiency 49 0 trials
-
T-B- severe combined immunodeficiency 0 trials · 14 incl. sub-types
16 sub-types
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency 6 trials
- Omenn syndrome 4 trials
- Severe combined immunodeficiency due to DCLRE1C deficiency 3 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive 2 trials
- DNA ligase IV deficiency 1 trial
- Reticular dysgenesis 1 trial Sub-types →
- Cernunnos-XLF deficiency 0 trials
- Combined immunodeficiency due to partial RAG1 deficiency 0 trials
- Combined immunodeficiency with skin granulomas 0 trials
- Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia 0 trials
- Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia 0 trials
- Neutrophil immunodeficiency syndrome 0 trials
- Reticular dysgenesis-like severe combined immunodeficiency 0 trials
- Severe combined immunodeficiency due to DNA-PKcs deficiency 0 trials
- Severe combined immunodeficiency due to LCK deficiency 0 trials
- Short-limb skeletal dysplasia with severe combined immunodeficiency 0 trials
-
T-B+ severe combined immunodeficiency 0 trials · 10 incl. sub-types
10 sub-types
- T-B+ severe combined immunodeficiency due to gamma chain deficiency 10 trials
- T-B+ severe combined immunodeficiency due to JAK3 deficiency 2 trials
- T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency 1 trial
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta 0 trials Sub-types →
- T-B+ severe combined immunodeficiency due to CD45 deficiency 0 trials
- Combined immunodeficiency, X-linked 0 trials
- Immunodeficiency 104 0 trials
- Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome 0 trials
- Severe combined immunodeficiency due to CORO1A deficiency 0 trials
- Severe combined immunodeficiency due to LAT deficiency 0 trials
-
2 sub-types
-
Immunodeficiency 79 0 trials
-
Janus kinase-3 deficiency 0 trials
Most studied deeper sub-types
-
Can a Precision-Engineered transplant rebuild immunity in babies born without it?
Cure OngoingInfants with severe combined immunodeficiency (SCID) lack working immune cells and face life-threatening infections. A matched sibling donor transplant is the standard cure, but most babies do not have one. This trial tests a refined transplant using a parent or other partially m…
Phase 1/2 • Sponsor: St. Jude Children's Research Hospital • Aim: Cure
Last updated Sep 18, 2026 00:00 UTC
-
Can lower chemo doses help babies with SCID build better immunity?
Disease control OngoingThis phase 2 trial studies whether lower doses of the chemotherapy drug busulfan can help infants with severe combined immunodeficiency (SCID) achieve good immune function after a stem cell transplant, while reducing short- and long-term risks. The trial includes 56 babies receiv…
Phase 2 • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
-
Stem cell transplant offers new hope for kids with rare immune diseases
Disease control OngoingThis study tests a donor stem cell transplant for people with severe immune system problems, like SCID and Wiskott-Aldrich syndrome. The goal is to help the body make healthy blood cells and fight infections. Participants receive donated stem cells to rebuild their immune system.…
Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
-
Milder stem cell transplant shows promise for kids with immune disorders
Disease control OngoingThis study tests a stem cell transplant using a milder chemotherapy-like regimen to treat children and young adults (up to age 28) with various immune system disorders. The goal is to help the donor stem cells settle in the body with fewer side effects. The study involves 20 part…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
-
Double transplant breakthrough offers hope for rare immune disorder patients
Disease control By invitation onlyThis study tests a new approach for people aged 5 to 45 with primary immune deficiencies and end-stage lung disease. Participants receive a double lung transplant followed by a stem cell transplant from the same donor. The goal is to see if this combined procedure is safe and can…
Phase 1/2 • Sponsor: Paul Szabolcs • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
-
SCID stem cell trial pulled before it began
Disease control CancelledThis study aimed to see if lower doses of chemotherapy drugs, with or without radiation, could safely prepare children and adults with SCID for a stem cell transplant. The goal was to help the donor cells take hold while avoiding severe side effects. However, the trial was withdr…
Phase 1/2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
-
New stem cell approach could fix immune systems in kids
Disease control OngoingThis Phase II trial tests a stem cell transplant from unrelated or partially matched family donors for children and young adults with severe immune deficiencies. The stem cells are specially processed to remove certain immune cells, aiming to reduce complications. The goal is to …
Phase 2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
-
Could methadone ease agonizing mouth pain in kids after transplant?
Symptom relief PausedThis study tests whether adding methadone to usual morphine-based pain medicine reduces severe mouth pain in children aged 6–18 who are getting a stem cell transplant for leukemia, aplastic anemia, or similar conditions. The mouth pain is a common side effect of the chemotherapy …
Phase 3 • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 07:55 UTC
-
Scientists collect skin cells to pave way for future immune disease cures
Knowledge-focused By invitation onlyThis study collects small skin samples from people with primary immunodeficiency or immune regulation disorders, as well as from healthy volunteers. Researchers will use these cells to create cell lines for laboratory research. The goal is to better understand immune diseases and…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
-
Gene therapy survivors monitored for decades in new study
Knowledge-focused By invitation onlyThis study follows 70 people who previously received gene therapy for a rare immune disorder called ADA-SCID. Researchers want to see how well the treatment worked over time and check for any long-term side effects. No new treatment is given—just regular health checkups.
Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC