Sciatic neuropathy
MONDO:0006960Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
78 clinical trials for this condition and its sub-types, 9 tagged with Sciatic neuropathy itself.
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Sub-types of Sciatic neuropathy
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Sciatica 47 trials · 69 incl. sub-types
1 sub-type
- Piriformis syndrome 25 trials
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Lesion of sciatic nerve 2 trials
2 sub-types
- Common peroneal nerve lesion 0 trials
- Plantar nerve lesion 0 trials
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New ultrasound test could spot sciatica faster
Diagnosis Recruiting nowThis study tests a new way to measure sciatic nerve stiffness using ultrasound (shear wave elastography) during leg movements. Researchers will compare 30 people with low back pain and sciatica to 30 healthy volunteers. The goal is to see if nerve stiffness differs between the gr…
Sponsor: Cairo University • Aim: Diagnosis
Last updated Jun 26, 2026 15:33 UTC
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Nerve flossing for athletes: a simple technique that could keep hamstrings strong?
Symptom relief Recruiting nowThis trial tests whether three types of nerve-gliding exercises — called neurodynamics — can improve hamstring strength and endurance in athletes aged 18 to 30 who play organized sports or train regularly. The exercises aim to improve nerve mobility and reduce pain, and the study…
Sponsor: High Point University • Aim: Symptom relief
Last updated Jul 24, 2026 00:00 UTC
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New shot for sciatica pain enters first human safety study
Symptom relief Recruiting nowThis early-stage study tests a single injection of C-1101 into the spine area for people with long-term sciatica (leg pain from a pinched nerve). The main goal is to check if the treatment is safe and tolerable compared to a saltwater placebo. Only 24 adults with pain that hasn't…
Phase 1 • Sponsor: Consano Bio • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Knee block mystery: does numbing agent reach the sciatic nerve?
Knowledge-focused Recruiting nowThis study looks at why a numbing injection in the thigh (adductor canal block) works so well for knee surgery pain. Researchers think the medicine may spread to the sciatic nerve, but they want to measure how often this happens. About 70 adults having knee surgery will be tested…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC