Respiratory distress syndrome in premature infants

This study tests whether giving the steroid betamethasone to extremely premature babies (born before 28 weeks) helps them come off breathing machines more easily and lowers their risk of chronic lung disease. About 100 babies will receive either standard NICU care plus betamethas…

This study tests whether a new breathing support called Pressure Targeted High Flow works as well as standard CPAP in premature infants with breathing problems. About 78 babies born before 33 weeks will try each method for 24 hours. Researchers will monitor breathing, oxygen need…

This study compares two types of high-frequency ventilators for premature babies born before 32 weeks who have breathing problems. The new mode, HFOV-VG, aims to deliver more stable breaths to reduce lung injury. Researchers will see if it lowers the chance of severe chronic lung…

This study tests whether giving a special lung medicine (surfactant mixed with budesonide) to extremely premature babies who are still on a breathing machine at 7-14 days old is safe and can help prevent a serious lung condition called bronchopulmonary dysplasia. About 24 babies …

This study tests whether a combination of three inhaled drugs (furosemide, heparin, and hypertonic saline) can reduce lung injury in adults with acute respiratory distress syndrome (ARDS) who are on mechanical ventilators. The trial will involve 344 participants and measure daily…

Researchers at Assiut University are testing whether lung ultrasound can diagnose pneumonia in newborns as reliably as the standard chest X-ray. The study will enroll 100 infants in the neonatal intensive care unit who have a clinical diagnosis of pneumonia within their first 28 …

This trial studies whether a slower inflation setting (long pressure rise time) on mechanical ventilators can improve oxygen levels in extremely preterm infants compared to the standard faster setting. About 68 babies born before 28 weeks will be randomly assigned to both setting…

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study aims to develop a new pain assessment scale, called EDEX, specifically for extremely premature infants born before 27 weeks. Current scales may not work well for these fragile babies, who show pain in subtle ways. Researchers will create the scale and then test it agai…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study will observe 184 adults with acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see how different machine settings affect lung injury and survival. The goal is to find safer ways to use ventilators for these critically ill pa…