Pure red-cell aplasia
MONDO:0001705A disease characterized by normocytic, normochromic anemia, low hematocrit, reticulocytopenia, and selective erythroid hypoplasia.
Also known as: PRCA, Pure Red Cell Aplasia, Acquired, pure red cell aplasia
33 clinical trials for this condition and its sub-types, 5 tagged with Pure red-cell aplasia itself.
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Sub-types of Pure red-cell aplasia
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Diamond-Blackfan anemia 17 trials
22 sub-types
- Diamond-Blackfan anemia 1 1 trial
- Diamond-Blackfan anemia 10 0 trials
- Diamond-Blackfan anemia 11 0 trials
- Diamond-Blackfan anemia 12 0 trials
- Diamond-Blackfan anemia 13 0 trials
- Diamond-Blackfan anemia 14 with mandibulofacial dysostosis 0 trials
- Diamond-Blackfan anemia 15 with mandibulofacial dysostosis 0 trials
- Diamond-Blackfan anemia 16 0 trials
- Diamond-Blackfan anemia 17 0 trials
- Diamond-Blackfan anemia 18 0 trials
- Diamond-Blackfan anemia 19 0 trials
- Diamond-Blackfan anemia 2 0 trials
- Diamond-Blackfan anemia 20 0 trials
- Diamond-Blackfan anemia 21 0 trials
- Diamond-Blackfan anemia 22 0 trials
- Diamond-Blackfan anemia 3 0 trials
- Diamond-Blackfan anemia 4 0 trials
- Diamond-Blackfan anemia 5 0 trials
- Diamond-Blackfan anemia 6 0 trials
- Diamond-Blackfan anemia 7 0 trials
- Diamond-Blackfan anemia 8 0 trials
- Diamond-Blackfan anemia 9 0 trials
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Adult pure red cell aplasia 2 trials
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Blood transfusion thresholds tested to save elderly surgical patients
Disease control CompletedThis study tests whether giving blood transfusions more liberally (when hemoglobin drops to 9 g/dL) versus more restrictively (when it drops to 7.5 g/dL) reduces death and serious complications like heart attack, stroke, or kidney injury in patients aged 70 and older undergoing n…
Phase 3 • Sponsor: Johann Wolfgang Goethe University Hospital • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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New hope for rare blood disorder: experimental pill reduces need for transfusions
Disease control CompletedThis study tested a drug called bitopertin in 15 adults with Diamond-Blackfan anemia (DBA), a rare inherited condition that causes severe anemia. Participants took the pill daily for 8 months, with doses possibly increasing over time. The goal was to see if the drug could raise h…
Phase 1/2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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New transplant cocktail aims to cut complications in bone marrow failure
Disease control CompletedThis phase 2 trial tested a combination of treosulfan, fludarabine, and rabbit antithymocyte globulin before a bone marrow transplant in 40 people with bone marrow failure diseases like Diamond-Blackfan anemia and Shwachman-Diamond syndrome. The goal was to see if this conditioni…
Phase 2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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One donor, two transplants: could this end lifelong Anti-Rejection drugs?
Disease control CompletedThis pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…
Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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New hope for rare anemia: drug combo shows promise
Disease control CompletedThis phase 2 trial tested a combination of two drugs, bortezomib and dexamethasone, in 18 adults with acquired pure red cell aplasia whose disease did not improve or came back after first treatment. The goal was to see if the combination could safely control the condition. The st…
Phase 2 • Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Anemia in kids may be tied to bigger hearts, study finds
Knowledge-focused CompletedThis study explored whether low hemoglobin (anemia) is linked to an enlarged heart (cardiomegaly) in children up to 18 years old. Researchers used chest X-rays and echocardiograms to check for heart enlargement in 56 anemic children. The goal was to better understand how anemia a…
Sponsor: Universitas Sumatera Utara • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC