Pulmonary emphysema

This trial is testing an investigational drug called brenipatide in adults with moderate-to-severe COPD. Participants will receive either brenipatide or a placebo for about a year, alongside standard care. The goal is to see if brenipatide improves lung function and reduces the n…

This trial investigates a surgical procedure to divide the fissure between lung lobes in people with COPD and emphysema who did not improve after endobronchial valve treatment. The goal is to see if the surgery is safe and feasible, potentially leading to better lung collapse and…

This study tests whether higher doses of the drug Respreeza/Zemaira can slow lung damage better than the standard dose in adults with emphysema caused by Alpha-1 antitrypsin deficiency. About 270 participants will receive weekly IV infusions for 3 years. The goal is to find the o…

This study tests whether a special scan (VQDI) can help doctors pick the best lung area to place tiny valves for severe emphysema. About 285 participants will be randomly assigned to have valve placement guided by either the new scan or the usual CT scan. The goal is to see if th…

This study tests whether adding a blood flow restriction cuff to aerobic exercise helps people with emphysema or COPD build muscle and improve daily function. Sixty participants will either do standard aerobic exercise or the same exercise with the cuff. The goal is to see if thi…

This study aims to find out how often people with FLNA gene mutations develop emphysema, a type of lung disease. Researchers will use chest CT scans, blood tests, and lung function tests in 70 participants. The goal is to confirm if FLNA changes are a cause of unexplained emphyse…