Proliferative vitreoretinopathy
MONDO:0700115Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.
20 clinical trials for this condition and its sub-types, 7 tagged with Proliferative vitreoretinopathy itself.
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Sub-types of Proliferative vitreoretinopathy
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CAPN5-related vitreoretinopathy 0 trials
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Eye injection shows promise in preventing repeat retinal detachment
Disease control Not yet recruitingThis early-stage study tests whether an injection of the drug topotecan into the eye can safely prevent retinal detachment from coming back in people with a condition called proliferative vitreoretinopathy (PVR). About 50 adults having retinal detachment surgery will either recei…
Phase 1 • Sponsor: Massachusetts Eye and Ear Infirmary • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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New eye camera could spot retinal disease earlier
Knowledge-focused Not yet recruitingThis study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…
Sponsor: Stuart Terry Eye Associates • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Can eye scans and fluid predict who will develop a complication after retinal detachment repair?
Knowledge-focused Not yet recruitingThis study will enroll 50 adults with a specific type of retinal detachment to look for clues in eye fluid and images that might predict a complication called PVR. Participants will receive standard surgery plus extra non-invasive eye scans and a sample of their eye fluid taken d…
Sponsor: University College, London • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC