Prion disease
MONDO:0005429A transmissible disease that is caused by a protein that is able to induce abnormal folding of normal cellular proteins, leading to characteristic spongiform brain changes, which are associated with neuronal loss without an inflammatory response. Such disorders have typically long incubation periods, but are then generally rapidly progressive and are uniformly fatal.
Also known as: spongiform encephalopathy
11 clinical trials for this condition and its sub-types, 5 tagged with Prion disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Prion disease
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Creutzfeldt Jacob disease 4 trials · 7 incl. sub-types
3 sub-types
- Inherited Creutzfeldt-Jakob disease 5 trials
- Acquired Creutzfeldt-Jakob disease 0 trials Sub-types →
- Sporadic Creutzfeldt-Jakob disease 0 trials
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Fatal familial insomnia 4 trials
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Huntington disease-like 1 0 trials
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PrP systemic amyloidosis 0 trials
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Kuru 0 trials
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Scrapie 0 trials
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Sporadic fatal insomnia 0 trials
Most studied deeper sub-types
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Could a single injection silence fatal brain disease?
Disease control Recruiting nowThis study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the …
Phase 1 • Sponsor: Broad Institute of MIT and Harvard • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Can a Long-Term watch program unlock the secrets of genetic prion disease?
Knowledge-focused Recruiting nowThis study follows adults with a family history of genetic prion disease to see how and when the condition first appears. Participants undergo regular check-ins and genetic testing over many years. The goal is to map the natural course of the disease and identify early markers th…
Sponsor: Brian Appleby • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists hunt for clues to predict rare brain disease before symptoms strike
Knowledge-focused Recruiting nowThis study aims to find biological markers in spinal fluid and blood that could signal the start of prion disease before symptoms appear. Researchers will follow 150 people who carry a genetic mutation for prion disease, along with family members and healthy volunteers. Participa…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC