Please sign in to follow a disease.
Primary syphilis
MONDO:0002896The subclinical or symptomatic stage of syphilis, occurring at an average of three weeks after contact with an infected individual. It manifests with one or more painless, indurated ulcers (chancres) of the skin or mucous membranes at the site of inoculation. These lesions heal spontaneously within a few weeks.
Also known as: early syphilis, symptomatic
16 clinical trials for this condition and its sub-types, 7 tagged with Primary syphilis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
-
Could a simple pill replace the shot for syphilis?
Cure CompletedThis study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Cure
Last updated Jun 27, 2026 07:58 UTC
-
Could a pill replace the syphilis shot? new trial tests oral antibiotic
Disease control CompletedThis trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assig…
Phase 3 • Sponsor: Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
-
New antibiotic shows promise for newborns with dangerous infections
Disease control CompletedThis study looked at how the antibiotic cefiderocol works in hospitalized infants under 3 months old with suspected or confirmed gram-negative bacterial infections. Researchers measured drug levels in the blood and checked for side effects in 30 babies. The goal was to find the r…
Phase 2 • Sponsor: Shionogi • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
-
New antibiotic shows promise for kids with tough infections
Disease control CompletedThis study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…
Phase 2 • Sponsor: Shionogi • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
-
New antibiotic shows promise for kids with tough infections
Disease control CompletedThis study tested a new antibiotic called MK-7655A in 115 children from birth to 18 years old who had serious bacterial infections. The goal was to see if the drug is safe and works better than standard treatments. Children were randomly assigned to receive either the new drug or…
Phase 2/3 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
-
New rapid syphilis test put to the test in vancouver clinic
Diagnosis CompletedThis study checked how well a new rapid test (Reveal TP) detects syphilis compared to standard lab tests. About 600 adults visiting a Vancouver STI clinic took part. The goal was to see if the quick finger-prick test is accurate enough for routine use.
Sponsor: MedMira Laboratories Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 08:14 UTC
-
Can a pill and a vaccine stop STIs in High-Risk men?
Prevention CompletedThis study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…
Phase 3 • Sponsor: ANRS, Emerging Infectious Diseases • Aim: Prevention
Last updated Jun 27, 2026 12:04 UTC