Primary syphilis
MONDO:0002896The subclinical or symptomatic stage of syphilis, occurring at an average of three weeks after contact with an infected individual. It manifests with one or more painless, indurated ulcers (chancres) of the skin or mucous membranes at the site of inoculation. These lesions heal spontaneously within a few weeks.
Also known as: early syphilis, symptomatic
16 clinical trials for this condition and its sub-types, 7 tagged with Primary syphilis itself.
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Could a simple pill replace the shot for syphilis?
Cure CompletedThis study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Cure
Last updated Jun 27, 2026 07:58 UTC
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Could a pill replace the syphilis shot? new trial tests oral antibiotic
Disease control CompletedThis trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assig…
Phase 3 • Sponsor: Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New rapid syphilis test put to the test in vancouver clinic
Diagnosis CompletedThis study checked how well a new rapid test (Reveal TP) detects syphilis compared to standard lab tests. About 600 adults visiting a Vancouver STI clinic took part. The goal was to see if the quick finger-prick test is accurate enough for routine use.
Sponsor: MedMira Laboratories Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 08:14 UTC