Primary progressive aphasia
MONDO:0019806Primary progressive aphasia (PPA) is a neurodegenerative disorder, characterized by a primary dissolution of language, with relative sparing of other mental faculties for at least the first 2 years of illness. PPA is recognized as the language variant in the frontotemporal dementia (FTD) spectrum of disorders. PPA can be classified into 3 subtypes based on specific speech and language features: semantic dementia (SD), progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (lv-PPA).
Also known as: Mesulam syndrome, PPA, primary progressive aphasia syndrome
71 clinical trials for this condition and its sub-types, 42 tagged with Primary progressive aphasia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Primary progressive aphasia
-
GRN-related frontotemporal lobar degeneration with Tdp43 inclusions 6 trials · 47 incl. sub-types
1 sub-type
- Progressive non-fluent aphasia 24 trials · 44 incl. sub-types Sub-types →
-
Logopenic progressive aphasia 16 trials
Most studied deeper sub-types
-
Gentle zaps to the brain may ease language loss in dementia
Symptom relief CompletedThis study tested whether a gentle, non-invasive brain stimulation technique called tDCS, combined with language therapy, could improve speech in 23 people with primary progressive aphasia (PPA). Participants received either real or fake (sham) stimulation daily for 10 days. Rese…
Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
-
Zapping the brain to save speech: new hope for aphasia?
Symptom relief CompletedThis study tested whether a gentle electrical current applied to the brain (tDCS) can improve language when combined with speech therapy in people with primary progressive aphasia (PPA), a condition that slowly damages language abilities. 76 adults with two types of PPA received …
Phase 2 • Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
-
Tiny study aims to unlock secrets of stuttering and aphasia
Knowledge-focused CompletedThis study looks at how the brain plans and produces speech in people who stutter, those with primary progressive aphasia, and healthy speakers. Participants will practice saying made-up words with tricky sound combinations while researchers measure brain activity with MRI and tr…
Sponsor: Boston University Charles River Campus • Aim: Knowledge-focused
Last updated Jul 26, 2026 00:00 UTC
-
New brain scan tracks Dementia-Linked tau buildup in rare language disorders
Knowledge-focused CompletedThis study tested a special PET scan tracer (F-18 AV 1451) to see how much tau protein builds up in the brains of 81 people with primary progressive aphasia or frontotemporal dementia. Researchers compared these scans to those of healthy controls to find unique patterns for each …
Phase 1 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC