Primary orthostatic hypotension
MONDO:0015914Primary orthostatic hypotension is a rare type of orthostatic hypotension. It is not a disease per se, but a condition caused by several disorders that affect a specific part of the autonomic nervous system, such as multiple system atrophy, young-onset Parkinson's disease, pure autonomic failure, dopamine beta-hydroxylase deficiency, familial dysautonomia, and pure autonomic failure among others. The autonomic nervous system is the part of the nervous system that regulates certain involuntary body functions such as heart rate, blood pressure, sweating, and bowel and bladder control. Orthostatic hypotension is a form of low blood pressure that happens when standing-up from sitting or lying down. Common symptoms may include dizziness, lightheadedness, generalized weakness, leg buckling, nausea, blurry vision, fatigue, and headaches. Additional symptoms can include chest pain (angina), head and neck pain (often affecting neck and shoulders with a coat hanger distribution), decline in cognitive functioning such as difficulty concentrating, temporary loss of consciousness or “blackout”. Some people with primary orthostatic hypotension may also have high blood pressure when lying down. The treatment depends upon several factors including the specific underlying cause including The treatment depends upon several factors including the specific underlying cause and may include physical counter-maneuvers like lying down, sitting down, squatting clenching buttocks, leg crossing, and support garment and medication.
Also known as: neurogenic orthostatic hypotension
83 clinical trials for this condition and its sub-types, 12 tagged with Primary orthostatic hypotension itself.
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Browse by category →Sub-types of Primary orthostatic hypotension
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Inherited orthostatic hypotension 0 trials · 71 incl. sub-types
3 sub-types
- Postural orthostatic tachycardia syndrome 71 trials
- Orthostatic hypotension 1 0 trials
- Orthostatic hypotension 2 0 trials
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Two-Drug combo aims to fix standing blood pressure drop without Lying-Down spike
Disease control By invitation onlyThis study tests whether combining two drugs, droxidopa and pyridostigmine, can improve a sudden drop in blood pressure when standing up (orthostatic hypotension) without making high blood pressure worse when lying down. The trial enrolls people with neurogenic orthostatic hypote…
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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New drug aims to stop the dizziness of standing up
Symptom relief OngoingThis study tests a new drug called CST-3056 in 12 adults with neurogenic orthostatic hypotension (a sharp drop in blood pressure when standing) caused by Parkinson's disease or pure autonomic failure. The goal is to see if the drug can improve blood pressure and reduce symptoms l…
Phase 2 • Sponsor: CuraSen Therapeutics, Inc. • Aim: Symptom relief
Last updated Aug 30, 2026 00:00 UTC
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New pill aims to stop dangerous blood pressure drops in rare brain disease
Symptom relief OngoingThis phase 3 study tests a drug called ampreloxetine for people with multiple system atrophy (MSA) who experience dizziness and fainting due to low blood pressure when standing. About 102 adults with MSA will take the drug for 20 weeks, then some will switch to placebo to see if …
Phase 3 • Sponsor: Theravance Biopharma • Aim: Symptom relief
Last updated Jun 26, 2026 13:24 UTC