Primary hyperparathyroidism
MONDO:0010837Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones.
Also known as: primary hyperparathyroidism, primary hyperparathyroidism (disease)
58 clinical trials for this condition and its sub-types, 23 tagged with Primary hyperparathyroidism itself.
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Sub-types of Primary hyperparathyroidism
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Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types
5 sub-types
Most studied deeper sub-types
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Is surgery better than watching for seniors with high calcium?
Disease control CompletedThis study looked at whether surgery helps people over 65 with mild primary hyperparathyroidism (high calcium levels) compared to just monitoring them. The goal was to see if surgery improves bone density and lowers fracture risk. A total of 102 participants were randomly assigne…
Sponsor: Region Skane • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New PET scan spots hidden parathyroid tumors better than standard test?
Diagnosis CompletedThis study tested a special PET scan (18F-fluorocholine) to see if it could better locate overactive parathyroid glands (adenomas) in people with hyperparathyroidism. 139 participants received the scan before surgery, and the results were compared to standard imaging and the actu…
Phase 3 • Sponsor: Thomas Hope • Aim: Diagnosis
Last updated Jun 27, 2026 12:25 UTC
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Glowing glands: camera may speed up parathyroid surgery
Symptom relief CompletedResearchers test whether a camera called Fluobeam helps surgeons locate parathyroid glands faster during surgery for mild primary hyperparathyroidism. The trial enrolls adults with this condition who need surgery. Half the participants undergo surgery with the camera, and half wi…
Sponsor: Nantes University Hospital • Aim: Symptom relief
Last updated Sep 16, 2026 00:00 UTC
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Glow-in-the-Dark tool may make parathyroid surgery safer and faster
Symptom relief CompletedThis study tested a device called PTeye that uses near-infrared light to help surgeons spot parathyroid glands during surgery for hyperparathyroidism. The goal was to see if it could reduce the number of tissue samples sent to the lab and lower the risk of needing a second surger…
Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Could a simple pill replace IV tests for parathyroid disease?
Knowledge-focused CompletedThis study tests whether a single dose of the drug cinacalcet can be used to measure how well the body suppresses parathyroid hormone (PTH). Researchers compare this pill-based test to the standard intravenous calcium test in healthy adults, and also compare results between healt…
Phase 4 • Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Ultrasound first: could it replace radiation scans for parathyroid patients?
Knowledge-focused CompletedThis study tested whether using ultrasound as the first imaging step before parathyroid surgery can safely reduce the need for radiation-based scans. 99 adults with primary hyperparathyroidism were enrolled. Those with clear ultrasound results went straight to surgery; others had…
Sponsor: Odense University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC