Primary brain neoplasm

This study tests a new drug called CBL0137 in children and young adults (ages 1 to 21) whose solid tumors, brain tumors, or lymphoma have returned or stopped responding to treatment. The goal is to find the best dose, check side effects, and see if the drug can shrink tumors. The…

This study tests a drug called repotrectinib in children and young adults (up to age 25) with advanced solid tumors, lymphoma, or brain tumors that have specific gene changes (ALK, ROS1, or NTRK1-3). The goal is to find the safest dose and see if the drug shrinks tumors. Particip…

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, including those with changes in the MYC or MYCN genes. The trial has two phases: first, finding the right dose, then checking if it works. Participants receive PLX038 intravenously every three weeks…

This study is tracking 600 people with brain tumors who receive GammaTile therapy during surgery. GammaTile is a device that delivers radiation directly to the tumor site to help prevent regrowth. Researchers are measuring how long tumors stay under control and how patients feel …

This study is testing a drug called Lutathera in children and young adults (ages 4 to 39) whose brain tumors have come back or are growing despite treatment. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dos…

This phase 2 trial tests belvarafenib, a daily pill that targets cancers with a BRAF mutation, in people with primary or metastatic brain tumors. Participants take the drug for about six months, and doctors monitor tumor response with scans. The goal is to see if the drug can con…

This early-stage trial tests a new combination treatment for children and young adults (ages 3-39) with recurrent malignant brain tumors that can be surgically removed. The treatment uses two genetically modified viruses injected into the tumor site, plus an oral anti-herpes drug…

This early-phase trial tests a new drug called ONC206 in children and young adults with diffuse midline glioma or other recurrent brain tumors. The drug aims to kill cancer cells by causing stress in them, without harming healthy cells. Researchers are looking for the safest dose…

This phase 2 trial tests the drug avapritinib in 50 adults with advanced solid tumors that have mutations in the CKIT or PDGFRA genes. The drug blocks enzymes that help cancer cells grow. The main goal is to see how many patients' tumors shrink or disappear. Researchers will also…

This early-phase study tests whether dapagliflozin, a diabetes medicine, is safe for children with brain or solid tumors that have come back or not responded to other treatments. About 20 children will receive the drug alongside standard care. The goal is to check for side effect…

This study tests a new cancer drug, repotrectinib, combined with standard chemotherapy in children and young adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combination can shrink tumors. Researchers will also study how the b…

This study tests whether adding the chemotherapy drug capecitabine to the standard temozolomide regimen can help people with newly diagnosed glioblastoma live longer without their tumor growing. About 67 adults who have completed initial radiation and chemo will take both pills a…

This phase 3 trial tests whether brain tumor patients who have been seizure-free for 6 months on levetiracetam can safely stop the drug earlier than the standard 2-3 years. 604 adults with primary brain tumors and controlled seizures will be randomly assigned to stop levetiraceta…

This early-phase trial is testing whether adding the drug ibrutinib to a chemo-immunotherapy regimen can safely help children and young adults (ages 6–25) with brain cancers that have come back or not responded to standard treatment. The study combines ibrutinib with indoximod an…

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor r…

This early study tests a special helmet that uses focused ultrasound to temporarily open the blood-brain barrier in people with glioblastoma. The goal is to let more chemotherapy reach the tumor. Ten adults who have already had surgery and standard chemo will receive the ultrasou…

This early-phase study tests a special imaging agent called hyperpolarized pyruvate to see if it can help doctors better diagnose glioma, a type of brain tumor. About 13 adults with brain tumors will receive the agent before an advanced MRI scan. The goal is to improve how tumors…

This study is testing a new virtual therapy program called FearLess, designed to help people with primary malignant brain tumors and their caregivers cope with the intense fear that their cancer might come back. The program involves 8 weekly one-on-one video sessions with a thera…

This pilot trial tests whether a supervised, group exercise program called Exercise Together is safe and feasible for people with primary brain tumors and their caregivers. The program uses resistance training to strengthen muscles used in daily activities and is designed to fost…

This study tests whether taking a daily vitamin B6 supplement can reduce anger and mood changes caused by the seizure drug levetiracetam in people with brain tumors. Fifty adults with brain tumor-related epilepsy who have been on levetiracetam for 6 weeks to 6 months will take 10…

This study tests whether special education programs can improve quality of life for people with brain tumors and reduce the burden on their caregivers. About 72 patients and their caregivers will take part. Researchers will measure quality of life and caregiver stress before and …

This study compares two 8-week virtual programs for adults with brain tumors who have thinking or memory issues. One program combines cognitive rehab with mindfulness (C-SMART), the other provides educational videos (BE Well). Researchers want to see if these programs are practic…

This study tests whether a 6-week occupational therapy group programme can improve quality of life and daily functioning in adults with primary brain tumours who are on active treatment. Participants are randomly assigned to either the group programme or usual care (written infor…

This study tests a virtual, home-based exercise program for teens and young adults who had a brain tumor and received radiation. The goal is to see if the program helps with memory and attention problems, and how it affects gut bacteria. About 60 participants will be randomly ass…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.

This study looks at how radiation therapy changes the brain's resting state networks in children and teens (ages 8-21) with newly diagnosed brain tumors. Participants will have MRI scans and cognitive tests before and about a year after proton radiation. The goal is to understand…

This study follows 300 adults with primary brain tumors (such as glioma or meningioma) who are receiving partial brain radiation. Researchers use brain scans and memory, attention, and language tests before and after treatment to understand how radiation affects thinking skills. …

This study tests a handheld microscope called CONVIVO that gives surgeons real-time, high-resolution images of brain tissue during surgery. The goal is to see if it can easily tell healthy tissue from tumor tissue in 30 patients with brain tumors. If it works, it could help surge…

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study tests a special brain-mapping grid placed during surgery to better identify areas that control movement and speech. Researchers will compare this method with standard techniques in 75 adults with brain tumors. The goal is to see if the new grid helps surgeons avoid dam…

This study will test whether computer-based thinking assessments are practical for children aged 4 to 21 with brain tumors who are receiving proton beam radiation therapy. Researchers will measure thinking skills before, during, and after treatment to see how radiation affects me…

This pilot study is testing whether a special MRI scan can measure a substance called 2-hydroxyglutarate (2HG) in brain tumors (gliomas) without needing surgery. Researchers will compare the MRI results with measurements from actual tumor tissue removed during surgery. If the MRI…

This study at MD Anderson Cancer Center tests whether advanced MRI (AMRI) can help doctors better target brain tumor biopsies. About 62 adults with brain lesions will get an AMRI scan before standard surgery. Researchers compare biopsy results from AMRI-guided spots to those from…

This study aims to standardize care for people with rare brain tumors by using artificial intelligence to analyze patient data and predict recovery after surgery. Researchers will collect information on symptoms, brain scans, and cognitive function from 200 adults undergoing tumo…

This observational study aims to find blood markers that show brain injury caused by cancer treatments in children with brain tumors. Researchers will collect plasma samples from 560 children before and after surgery, during radiation or chemotherapy, and up to three years later.…

This study uses brain mapping techniques like fMRI and MEG before, during, and after surgery to see how brain functions like movement and speech reorganize in people with brain tumors. Researchers hope to improve surgical planning and preserve important brain functions. The study…

This study is creating a collection of blood samples from 300 adults with primary or metastatic brain tumors. Researchers will analyze immune cells in the blood to better understand these tumors. The goal is to provide a resource for future studies, not to test a new treatment.

This study aims to collect and analyze genetic information from 250 adults in Taiwan diagnosed with diffuse gliomas, a type of brain tumor. Researchers will use tumor tissue and blood samples to identify genetic patterns. The goal is to better understand why these tumors are so h…