Primary brain neoplasm

This early-stage trial is testing an experimental drug called APX005M in 32 children with brain tumors that have come back or are hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack cancer cells. The main goals are to fin…

This early-phase study tested a method called convection-enhanced delivery to pump the chemotherapy drug topotecan directly into brain tumors in 16 patients with recurrent malignant brain tumors. The goal was to see if this approach is safe and to find the best dose, while also m…

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

This completed Phase 1 trial tested whether a dye called indocyanine green (ICG) can make brain tumor cells glow during surgery, helping surgeons see and remove them more completely. 363 adults with brain tumors received an ICG injection before surgery, and special cameras captur…

This study tests whether a fluorescent dye called tozuleristide, given before surgery, can make brain tumor tissue glow under a special imaging system. Surgeons can then see and remove more of the tumor while sparing healthy brain. The trial enrolls adults with certain types of b…

This study tested a radioactive sugar-like tracer called 99mTc-1-thio-D-glucose to see if it can make brain tumors visible on SPECT scans. Sixteen adults with primary or recurrent brain tumors received one injection, then had scans at several time points. Researchers measured how…

This completed Phase 3 trial tested whether Elucirem (gadopiclenol) provides better MRI images of brain gliomas compared to the standard contrast agent Dotarem. 138 adults with primary or recurrent brain tumors received one of the two agents during DSC-MRI perfusion scans. The ma…

This study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…

This study tested whether a computer-based cognitive training program could help children with brain tumors who had radiation therapy. 45 children were randomly assigned to either an adaptive or non-adaptive training program. The goal was to see if the training could improve thin…

This study tested whether using a virtual reality (VR) headset at home could help reduce anxiety and distress in adults with primary brain tumors. Sixty-one participants used the VR headset for 4 weeks and filled out symptom questionnaires. The goal was to see if this approach is…

This study tested whether a web-based tool called eSNAP, combined with a caregiver navigator, could help family caregivers of brain cancer patients feel less anxious and burdened. The tool helps caregivers map out their support network, while the navigator provides guidance. Rese…

This pilot study tested a telehealth program called C-SMART for people with primary brain tumors who have mild memory or thinking problems. The program combines cognitive rehabilitation with mindfulness training over 8 weekly sessions. Researchers enrolled 32 patients and caregiv…

This study tested a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) in 70 people with brain tumors who also had trouble sleeping. The therapy involved six weekly group sessions delivered online. The main goal was to see if the approach was practical …

This study looks at long-term hormone and metabolic problems in people who survived a childhood brain tumor. Researchers will check survivors for issues like growth, thyroid, and blood sugar problems, and see how these relate to the tumor and its treatment. The goal is to help do…

This study developed and tested a program to help nurses better support relatives of patients with acquired brain injury or malignant brain tumors. The program included nurse training, a dialog tool, a peer support list, videos, and documentation guidelines. Researchers tested it…

This completed study from Mayo Clinic interviewed 33 adults with brain or central nervous system (CNS) tumors, along with their caregivers, to learn about their biggest challenges and needs. The goal was to identify areas where doctors and healthcare teams can offer better suppor…

This study examined 12 childhood brain tumor survivors to understand long-term hormone and metabolic problems. Researchers checked for issues like growth hormone deficiency, thyroid problems, obesity, and abnormal cholesterol. The goal is to help doctors better monitor and manage…