Preretinal fibrosis
MONDO:0002174A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Also known as: macular puckering of retina
35 clinical trials for this condition and its sub-types, 21 tagged with Preretinal fibrosis itself.
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AI eye scanner could catch retina disease earlier
Diagnosis Recruiting nowThis study evaluates PathFinder 1.0, a software that analyzes OCT images of the retina to detect macular abnormalities such as epiretinal membrane, dry age-related macular degeneration, and other retinal conditions. About 400 adults with and without macular issues will undergo st…
Sponsor: Carl Zeiss Meditec-Dublin CoCe • Aim: Diagnosis
Last updated Aug 30, 2026 00:00 UTC
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Robot takes on delicate eye surgery
Symptom relief Recruiting nowResearchers are testing a robotic surgical system called Luca for people who need vitreoretinal surgery to treat conditions such as vitreous hemorrhage and macular pucker. The study enrolls up to 15 adults aged 18 to 85 who are scheduled for this type of eye surgery. Doctors use …
Sponsor: Acusurgical • Aim: Symptom relief
Last updated Sep 13, 2026 00:00 UTC
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New eye implant could replace drops after retina surgery
Symptom relief Recruiting nowThis study tests a tiny gel-like insert placed in the tear duct that releases dexamethasone, a steroid, to reduce pain and swelling after vitreoretinal surgery. It compares the insert to standard steroid eye drops in 30 adults undergoing surgery for conditions like macular holes …
Phase 4 • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
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Which eye surgery machine is faster? new study puts UNITY VCS to the test
Knowledge-focused Recruiting nowThis study compares two surgical systems used for combined cataract and vitrectomy eye surgeries. The UNITY VCS system is being tested against the CONSTELLATION system to see which one surgeons find more efficient in real-world operating rooms. About 180 adults needing combined e…
Sponsor: Alcon Research • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC
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Timing of eye surgery under the microscope: early or late?
Knowledge-focused Recruiting nowThis study compares immediate surgery versus waiting for vision to worsen in people with an epiretinal membrane (a thin layer of scar tissue on the eye's surface). It includes 400 adults with relatively good vision (20/40 or better) who have symptoms like blurring or distortion. …
Sponsor: Jaeb Center for Health Research • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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New lens hope for cataract patients with eye membrane
Knowledge-focused Recruiting nowThis study looks at 90 cataract patients who also have an epiretinal membrane (a thin layer on the retina). Researchers want to see if a special "functional" lens implant helps them see better without glasses compared to a standard lens. Participants will have their vision checke…
Sponsor: Eye & ENT Hospital of Fudan University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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New microscope camera could make eye surgery safer and more precise
Knowledge-focused Recruiting nowThis study tests a special microscope that takes live 3D images inside the eye during surgery. It aims to help surgeons see better when treating conditions like retinal detachment, macular holes, and cataracts. About 262 people will take part, including healthy volunteers and sur…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC