Precancerous condition
MONDO:0021074A pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia.
Also known as: precancerous condition, precancerous state, premalignant condition, premalignant state
518 clinical trials for this condition and its sub-types, 51 tagged with Precancerous condition itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Precancerous condition
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In situ carcinoma 25 trials · 318 incl. sub-types
21 sub-types
- Breast carcinoma in situ 76 trials · 204 incl. sub-types Sub-types →
- Adenocarcinoma in situ 10 trials · 170 incl. sub-types Sub-types →
- Bladder carcinoma in situ 30 trials
- Intestine carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Uterus carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Esophagus carcinoma in situ 13 trials
- Squamous carcinoma in situ 5 trials · 10 incl. sub-types Sub-types →
- Skin carcinoma in situ 3 trials · 9 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Stomach carcinoma in situ 4 trials Sub-types →
- Lung carcinoma in situ 2 trials · 3 incl. sub-types Sub-types →
- Pharynx carcinoma in situ 0 trials · 2 incl. sub-types Sub-types →
- Larynx carcinoma in situ 1 trial Sub-types →
- Carcinoma in situ of ureter 0 trials
- Carcinoma in situ of urethra 0 trials
- Eye carcinoma in situ 0 trials
- Gall bladder carcinoma in situ 0 trials
- Grade III prostatic intraepithelial neoplasia 0 trials
- Kidney carcinoma in situ 0 trials Sub-types →
- Liver carcinoma in situ 0 trials Sub-types →
- Nasal cavity carcinoma in situ 0 trials
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Intraepithelial neoplasia 25 trials · 71 incl. sub-types
3 sub-types
- Squamous cell intraepithelial neoplasia 26 trials · 43 incl. sub-types Sub-types →
- Prostate intraepithelial neoplasia 2 trials Sub-types →
- Small intestinal intraepithelial neoplasia 1 trial
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Pre-malignant neoplasm 2 trials · 43 incl. sub-types
1 sub-type
- Actinic keratosis 41 trials
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Leukoplakia 7 trials · 28 incl. sub-types
5 sub-types
- Oral mucosa leukoplakia 23 trials Sub-types →
- Esophageal leukoplakia 1 trial
- Leukoplakia of penis 0 trials
- Leukoplakia of vagina 0 trials
- Uterine cervix leukoplakia 0 trials
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Premalignant hematological system disease 3 trials · 25 incl. sub-types
2 sub-types
- Clonal hematopoiesis 10 trials · 22 incl. sub-types Sub-types →
- Atypical lymphoproliferative disorder 0 trials
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Gastric intestinal metaplasia 18 trials
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Preneoplastic lesion 8 trials
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Neoplastic polyp 1 trial · 5 incl. sub-types
1 sub-type
- Polyposis 3 trials · 4 incl. sub-types Sub-types →
Most studied deeper sub-types
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Lower drug dose after transplant may cut infections without losing protection
Disease control OngoingThis study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease (a common complication where donor cells att…
Phase 2 • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New robot could transform hysterectomy surgery
Disease control OngoingThis study is testing a new robotic system, the Medtronic Hugo™, for performing hysterectomies. It includes 70 patients with conditions like uterine fibroids, endometriosis, or certain cancers. The goal is to see if the robot is safe and can complete the surgery without switching…
Sponsor: Medtronic - MITG • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Donor stem cell transplant shows promise for tough blood cancers
Disease control OngoingThis study tests a stem cell transplant from a matched unrelated donor for people with advanced blood cancers or blood disorders. Patients get chemotherapy and radiation before the transplant to prepare their body, then take drugs to prevent the donor cells from attacking their o…
Phase 2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New heat therapy for pancreatic lesions tested in 100-Patient registry
Disease control OngoingThis study tracks 100 people with pancreatic cysts or tumors who receive a treatment called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA). A thin needle delivers heat directly to the lesion to destroy it. Researchers will monitor how well the procedure works and …
Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New hope for blood cancer patients: using mismatched donors for transplants
Disease control OngoingThis study tests a stem cell transplant using donors who are not a perfect match for patients with blood cancers like leukemia and lymphoma. Doctors give special drugs after the transplant to help prevent the donor cells from attacking the patient's body. The goal is to see if th…
Phase 2 • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Can a cancer drug stop lung cancer before it starts?
Disease control OngoingThis study tests whether the drug nivolumab (Opdivo) can reverse early, pre-cancerous changes in the lungs of current or former heavy smokers who are at high risk for lung cancer. Nineteen participants receive nivolumab to see if their lung tissue improves over six months. The go…
Phase 2 • Sponsor: University of Colorado, Denver • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Glow-in-the-Dark mouth scans could catch cancer early
Diagnosis OngoingThis study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…
Sponsor: M.D. Anderson Cancer Center • Aim: Diagnosis
Last updated Sep 16, 2026 00:00 UTC
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AI takes on esophageal cancer: could it spot the disease earlier?
Knowledge-focused By invitation onlyThis study is testing whether an artificial intelligence (AI) model can help doctors better detect, diagnose, and treat esophageal cancer. Researchers will feed de-identified data from 12,000 patients receiving routine care into the AI and compare its recommendations to standard …
Sponsor: The First Affiliated Hospital of Henan University of Science and Technology • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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Cancer tissue bank study aims to unlock new treatment clues
Knowledge-focused By invitation onlyThis study collects tissue and blood samples from 1,200 adults with known or suspected cancer. The samples are taken during standard surgeries or biopsies, with no extra procedures. Researchers will compare cancerous and normal tissues to identify differences that could lead to n…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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Hidden gene changes could reveal who gets cancer
Knowledge-focused OngoingThis study searches for new gene changes (mutations) that appear in cancer patients but not in their healthy parents. By comparing DNA from 1,275 people with certain cancers and their families, researchers hope to find genetic clues that increase cancer risk. The goal is to bette…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC