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POEMS syndrome
MONDO:0017364POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.
Also known as: Crow-Fukase syndrome, PEP syndrome, POEMS syndrome, Takatsuki syndrome, osteosclerotic myeloma, polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome, polyneuropathy organomegaly, polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome
13 clinical trials for this condition and its sub-types, 8 tagged with POEMS syndrome itself.
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Desperate patient gets own stem cells for rare nerve disease
Symptom relief Expanded access (ended)This study treated one 58-year-old man with polyneuropathy caused by POEMS syndrome using his own fat-derived stem cells. He received eight infusions over 28 weeks to try to relieve nerve symptoms. The study is no longer available and was not a formal clinical trial.
Sponsor: Hope Biosciences Research Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Can wearable sensors and walking tests reliably track nerve damage?
Knowledge-focused OngoingResearchers are checking whether tests of muscle strength, walking, balance, and fine motor skills give consistent results in people with polyneuropathy. About 520 adults with various forms of nerve damage, plus healthy volunteers, take part. Participants complete physical tests,…
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC