POEMS syndrome
MONDO:0017364POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.
Also known as: Crow-Fukase syndrome, PEP syndrome, POEMS syndrome, Takatsuki syndrome, osteosclerotic myeloma, polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome, polyneuropathy organomegaly, polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome
13 clinical trials for this condition and its sub-types, 8 tagged with POEMS syndrome itself.
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Can a Two-Drug combo tame a rare nerve and blood disorder?
Disease control CompletedThis phase II trial tests whether the combination of lenalidomide and dexamethasone can help people with POEMS syndrome, a rare blood disorder that damages nerves and causes other symptoms. Participants receive the drug combo either before local radiation or intensive treatment, …
Phase 2 • Sponsor: University Hospital, Limoges • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Laser test could objectively measure nerve pain for first time
Diagnosis CompletedThis study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…
Sponsor: University of Utah • Aim: Diagnosis
Last updated Jun 27, 2026 12:09 UTC