Piriformis syndrome
MONDO:0043320A condition referring to irritation or compression of the proximal sciatic nerve, secondary to contraction of the piriformis muscle. It results in pain in the hip or the back of the leg mimicking disk-related sciatica.
Also known as: piriformis muscle syndrome, piriformis syndrome, Pseudosciatica, deep gluteal syndrome, hip socket neuropathy, muscle syndrome, piriformis, muscle syndromes, piriformis, pelvic outlet syndrome
35 clinical trials for this condition and its sub-types, 25 tagged with Piriformis syndrome itself.
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Can a simple exam replace needles for piriformis diagnosis?
Diagnosis Not yet recruitingThis study aims to see if common physical exams and diagnostic criteria can accurately identify piriformis syndrome, a cause of buttock pain. Researchers will enroll 75 adults with gluteal pain and compare exam results to an ultrasound-guided lidocaine injection into the piriform…
Sponsor: Istanbul University - Cerrahpasa • Aim: Diagnosis
Last updated Jun 27, 2026 11:02 UTC
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Can a fluid injection between muscle layers ease piriformis pain?
Symptom relief Not yet recruitingResearchers are testing whether adding a procedure called interfascial hydrodissection to a standard ultrasound-guided piriformis injection helps adults with piriformis syndrome. The trial enrolls 110 people aged 18 to 70 who have buttock pain and signs of piriformis syndrome. Ev…
Sponsor: Haydarpasa Numune Training and Research Hospital • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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Can targeted muscle techniques outperform standard therapy for piriformis pain?
Symptom relief Not yet recruitingThis study tests whether two hands-on therapies—muscle energy technique and myofascial release—can improve pain, muscle strength, and activation in people with piriformis syndrome, a condition where a deep buttock muscle irritates the sciatic nerve. About 72 adults aged 18–65 wit…
Sponsor: Igdir University • Aim: Symptom relief
Last updated Aug 19, 2026 00:00 UTC
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Massage vs stretch: which eases piriformis pain better?
Symptom relief Not yet recruitingThis study compares two manual therapy techniques—myofascial release and post-isometric relaxation—for treating piriformis syndrome, a condition where a muscle in the buttock presses on the sciatic nerve, causing pain, numbness, and tingling. Twenty-six adults aged 20 to 50 with …
Sponsor: University of Faisalabad • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Gentle muscle moves may ease piriformis pain – which works best?
Symptom relief Not yet recruitingThis study compares two muscle energy techniques—post-isometric relaxation and reciprocal inhibition—for treating piriformis syndrome, a condition causing buttock pain and limited movement. Researchers will enroll 42 adults aged 25-40 with confirmed piriformis syndrome and modera…
Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Botox injection may ease stubborn buttock and leg pain
Symptom relief Not yet recruitingThis study tests whether injecting botulinum toxin (like Botox) into the piriformis muscle can reduce pain and improve quality of life in people with piriformis muscle syndrome. About 108 adults who have had buttock or leg pain for at least 3 months and haven't gotten relief from…
Phase 2 • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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New injection technique may offer longer relief for piriformis pain
Symptom relief Not yet recruitingThis study compares two treatments for buttock pain caused by piriformis syndrome and related muscle pain. Researchers will use ultrasound to guide either a sugar-water injection or a dry needle into the affected area. The goal is to see which method provides better pain relief o…
Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC