Peyronie disease
MONDO:0008231A condition characterized by hardening of the penis due to the formation of fibrous plaques on the dorsolateral aspect of the penis, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.
Also known as: Peyronie disease, Peyronie's disease, Peyronie's fibromatosis, penile fibromatosis, penile induration, penis fibromatosis
1438 clinical trials for this condition and its sub-types, 12 tagged with Peyronie disease itself.
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New surgery showdown: can a gentler technique fix penile curvature better?
Disease control Recruiting nowThis study compares two surgical techniques for men with complex Peyronie's disease, a condition causing painful penile curvature. Researchers will test whether a newer, microsurgery-based method (subtunical microdissection) works better than the standard plaque incision and graf…
Sponsor: Namik Kemal University • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Shockwave combo may boost penile curvature treatment
Disease control Recruiting nowThis study tests whether adding low-intensity shockwave therapy to standard Xiaflex injections can better reduce penile curvature in men with Peyronie's disease. Sixty participants will receive both treatments or Xiaflex alone. The goal is to improve sexual function and reduce bo…
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Shockwaves could ease Peyronie's: new trial tests Non-Surgical option
Symptom relief Recruiting nowThis study is testing whether extracorporeal shockwave therapy can help men with stable Peyronie's disease. The treatment uses sound waves applied to the penis to target scar tissue. Researchers will measure changes in erectile function and quality of life in 50 participants over…
Sponsor: Uskudar University • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Laser zaps penile scar tissue in early trial
Symptom relief Recruiting nowThis phase 1 trial tests whether a fractional CO2 laser can safely reduce the scar tissue that causes penile curvature in Peyronie's disease. Sixty men with stable, chronic disease will receive three laser sessions over 18 weeks. The main goal is to check for side effects, but re…
Phase 1 • Sponsor: Ottawa Hospital Research Institute • Aim: Symptom relief
Last updated Jun 26, 2026 17:46 UTC