Peptic ulcer disease

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This trial compares two medicines—tegoprazan and lansoprazole—for healing bleeding stomach ulcers. Adults with bleeding peptic ulcers receive one of the two drugs daily for 14 days, along with standard care like IV fluids and a stomach exam. A second exam after treatment checks w…

This study tests a new way to treat marginal ulcers that can form after gastric bypass surgery. Instead of just taking standard acid-reducing medication, some participants will also receive a low-thermal argon plasma treatment during an endoscopy. The goal is to see if this plasm…

This study compares a new hemostatic powder, Nexpowder™, to standard treatments (like clips, heat, or injections) for stopping high-risk bleeding in the upper digestive tract. About 278 adults with active bleeding from ulcers, tumors, or tears will be randomly assigned to one of …

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

This study tests whether a newer acid-reducing drug (vonoprazan) works better than a standard one (esomeprazole) for clearing H. pylori, a bacteria that can cause stomach ulcers and indigestion. About 80 adults with H. pylori will take one of the two drug combinations for 14 days…

This study looks at whether opening a capsule of the acid-blocking drug omeprazole helps heal stomach ulcers faster in people who have had gastric bypass surgery. About 122 participants will be randomly assigned to take the capsule whole or opened. Doctors will check ulcer healin…

This study compares an oral medication called Vonoprazan to the standard high-dose IV proton pump inhibitor (PPI) for preventing rebleeding in people with bleeding peptic ulcers after endoscopic treatment. About 594 adults will be randomly assigned to receive either oral Vonopraz…

This study tests three different anti-ulcer medications (Dexlansoprazole, Lansoprazole, and Vonoprazan) combined with two antibiotics (Levofloxacin and Amoxicillin) to see which works best for eradicating H. pylori infection. About 942 adults in Pakistan with H. pylori will take …

This study tests whether adding a probiotic called Saccharomyces boulardii to a standard antibiotic cocktail helps clear Helicobacter pylori infections that didn't respond to earlier treatments. About 1,248 adults who have failed prior H. pylori therapy will be randomly assigned …

This study tests whether adding bismuth to standard antibiotics works better than antibiotics alone to clear H. pylori infection and heal peptic ulcers in 80 children. Participants take a 14-day treatment, then continue acid-reducing medication for a few more weeks. Researchers w…

This study compares high-dose oral omeprazole (a common acid-reducing pill) against standard intravenous pantoprazole (given through a vein) in 128 adults who have had a bleeding stomach ulcer treated with endoscopy. The goal is to see if the oral pill is just as good at preventi…