Patent foramen ovale
MONDO:0020439A persistent opening in the atrial septum after birth. While a normal part of fetal circulation, the foramen ovale should close once the newborn begins breathing and the pressure in the left atrium exceeds that of the right atrium. While a PFO is generally asymptomatic, it can lead to the passage of clots from the venous circulation into the artierial circulation, resulting in paradoxical emboli, and possible strokes.
Also known as: ostium secundum type atrial septal defect, patent foramen ovale, patent foramen ovale (disease)
109 clinical trials for this condition and its sub-types, 36 tagged with Patent foramen ovale itself.
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App-Based exercise program aims to strengthen hearts in congenital disease
Disease control Stopped earlyThis study tests a remote, app-enabled exercise program designed for people aged 10 to 50 with congenital heart disease. Participants use a smartphone app with exercise modules and wearable devices to track heart rate and progress. The goal is to see if this approach can safely i…
Sponsor: Duke University • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Heart hole closure for migraines? tiny study halted early
Symptom relief Stopped earlyThis study tested whether closing a small hole in the heart (called a PFO) with a device could reduce migraine headaches. It planned to compare the real procedure to a sham (fake) procedure in adults aged 18-55 with frequent migraines. However, the study was stopped early after e…
Sponsor: W.L.Gore & Associates • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC