Pantothenate kinase-associated neurodegeneration
MONDO:0009319Pantothenate kinase-associated neurodegeneration (PKAN) is the most common type of neurodegeneration with brain iron accumulation (NBIA), a rare neurodegenerative disorder characterized by progressive extrapyramidal dysfunction (dystonia, rigidity, choreoathetosis), iron accumulation on the brain and axonal spheroids in the central nervous system.
Also known as: brain iron accumulation type I syndrome, Hallervorden-Spatz disease, Hallervorden-Spatz syndrome, NBIA1, PKAN, neurodegeneration with brain iron accumulation 1, neurodegeneration with brain iron accumulation type 1, pantothenate kinase-associated neurodegeneration
17 clinical trials for this condition and its sub-types, 4 tagged with Pantothenate kinase-associated neurodegeneration itself.
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Browse by category →Sub-types of Pantothenate kinase-associated neurodegeneration
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Vitamin compound studied for rare brain disease PKAN
Disease control CompletedThis study looked at how people with PKAN, a rare genetic brain disorder, respond to a special vitamin metabolite. Researchers wanted to see if it is safe and if it changes any signs of the disease. 77 people aged 3 months to 89 years took part.
Sponsor: Oregon Health and Science University • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Brain study sheds light on Parkinson's and tics
Knowledge-focused CompletedThis completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Wrist-Worn gadget could help doctors monitor Parkinson's at home
Knowledge-focused CompletedThis study tested a wrist-worn device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants wore the device while researchers compared its readings to standard clinical tests and video…
Sponsor: Global Kinetics Corporation • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC