Palmar fibromatosis
MONDO:0006345A superficial fibromatosis arising from the soft tissue of the palm. It is characterized by the presence of spindle-shaped fibroblasts, and an infiltrative growth pattern. It predominantly affects adult males.
Also known as: Dupuytren contracture, Dupuytren contracture (disease), palmar fibromatosis, palmar part of manus fibromatosis, Dupuytren's contracture
1452 clinical trials for this condition and its sub-types, 20 tagged with Palmar fibromatosis itself.
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Radiation may stop Dupuytren's hand disease in its tracks
Disease control Not yet recruitingThis phase 3 trial tests whether radiation therapy can prevent Dupuytren's contracture—a condition where fingers bend toward the palm—from progressing or coming back after treatment. About 158 adults will receive radiation to the hand, and researchers will measure changes in fing…
Phase 3 • Sponsor: Yale University • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Antioxidant pill may cut opioid use after surgery
Symptom relief Not yet recruitingThis study tests whether taking N-acetylcysteine (NAC), a common supplement, before and after hand or foot surgery can reduce pain and the need for opioid painkillers. About 80 adults will be randomly assigned to take NAC or a placebo for 14 days. Researchers will track pain, fun…
Phase 2 • Sponsor: University of Arizona • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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New heat therapy could ease Dupuytren's contracture without surgery
Symptom relief Not yet recruitingThis study tests whether TECAR therapy, a type of energy-based heat treatment, can reduce pain and improve hand movement in people with Dupuytren's contracture (palmar fibromatosis). Thirty-six adults aged 40 to 70 with mild to moderate finger contractures will receive 20-minute …
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Could skipping a common additive make numbing shots safer and just as effective?
Symptom relief Not yet recruitingThis study looks at whether leaving out bicarbonate from the numbing medicine (lidocaine with adrenaline) affects how well people recover the day after hand or foot surgery. About 150 adults having common procedures like carpal tunnel release or bunion surgery will be randomly as…
Phase 4 • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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New study aims to predict surgery needs for common hand condition
Knowledge-focused Not yet recruitingThis study will follow 305 adults with Dupuytren's disease, a hand condition that causes fingers to curl inward. Researchers want to find out how many people need surgery within 3 years after a less invasive needle treatment, and what factors might predict that need. The goal is …
Sponsor: Ramsay Générale de Santé • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Study explores how conversations shape patient choices on x-rays and MRIs
Knowledge-focused Not yet recruitingThis study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…
Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:22 UTC