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Antioxidant pill may cut opioid use after surgery

NCT ID NCT07227649

Symptom relief Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests whether taking N-acetylcysteine (NAC), a common supplement, before and after hand or foot surgery can reduce pain and the need for opioid painkillers. About 80 adults will be randomly assigned to take NAC or a placebo for 14 days. Researchers will track pain, function, and recovery using daily surveys and blood tests.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Elective outpatient hand/upper-extremity or foot/ankle surgery (single site; same-day discharge) * Baseline visit feasible ≤14 days pre-op * Can complete surveys/blood draw * Provides informed consent * Willing to follow dosing schedule and avoid restricted supplements/meds Exclusion Criteria: * Allergy to NAC/capsule components □ NAC or high-dose antioxidants in past 14 days (unwilling to stop) * Chronic daily opioids ≥3 months or OUD/maintenance therapy □ Pregnant/breastfeeding or no contraception as applicable * Daily nitrates (nitroglycerin/isosorbide) □ Planned \>24h admission, multistage/trauma case □ Other interventional study within 30 days * Unable to swallow capsules / malabsorption surgery affecting oral meds

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome de Quervain disease Morton neuroma palmar fibromatosis peroneal neuropathy plantar fasciitis tarsal tunnel syndrome trigger thumb ulnar neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carpal tunnel surgery De Quervain syndrome Dupuytren contracture Guyon's canal Morton neuroma Peroneal nerve entrapment Plantar fasciopathy Tarsal tunnel syndrome Trigger finger disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Banner Health

    Tucson, Arizona, 85721, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.