Palmar fibromatosis

This trial investigates whether targeted radiation therapy can stop Dupuytren's contracture from coming back after a collagenase injection and release procedure. Adults aged 45 and older with a finger that cannot lie flat will receive two 5-day courses of radiation separated by a…

This study tests a new drug called CNT201 for people with Dupuytren's contracture, a condition where fingers bend toward the palm and can't straighten. The drug is injected into the tight cord in the finger to break it down, aiming to restore movement. About 60 adults aged 18 to …

Dupuytren's disease causes fingers to bend inward, making hand use difficult. This study compares standard surgery (aponeurectomy) alone versus surgery plus a fat graft taken from the patient's arm. Researchers will track 172 adults for 2 years to see if the fat graft reduces the…

This study tests if a vitamin E treatment can shrink early-stage Dupuytren's nodules (painless lumps in the palm) and prevent them from turning into disabling finger contractures. About 80 adults with stage 0 Dupuytren's will receive either vitamin E or a placebo, and doctors wil…

This study tests whether removing a Dupuytren's cord during trigger finger surgery leads to less scarring and better hand function. Fifty adults with both conditions will be randomly assigned to have the cord removed or simply cut. Researchers will measure scar quality using two …

This study is testing whether adding radiation after surgery for Dupuytren's contracture leads to better hand function and fewer recurrences. Researchers will follow 50 patients who are already getting this treatment and ask them to fill out a questionnaire about their hand funct…

This study observes 80 adults with Dupuytren disease who are having surgery to remove thickened tissue in their hands. Researchers want to see if tiny nerve bundles found in the tissue, and whether they are cut during surgery, affect the chance of the disease coming back. They wi…

This study looks at whether ultrasound, a safe and painless imaging method, can help doctors better understand Dupuytren's disease—a condition that causes fingers to bend inward. Researchers will measure features like tissue brightness, skin involvement, and blood flow in 20 part…