Osteosarcoma

This study tests the drug regorafenib in 30 patients aged 9 to 21 with bone cancers (osteosarcoma or Ewing sarcoma) that have not responded to standard therapy. The goal is to see if the drug can help control the disease and improve survival, while also checking its safety. The a…

This phase 2 trial is testing whether combining two chemotherapy drugs, gemcitabine and oxaliplatin, can shrink tumors in children and adolescents with certain solid cancers that have come back or not responded to standard treatment. The study includes patients with medulloblasto…

This phase 2 trial tests whether the drug regorafenib can stop or slow the growth of metastatic bone sarcomas (cancers that started in bone and spread). 163 patients with osteosarcoma, Ewing sarcoma, chondrosarcoma, or chordoma are randomly assigned to receive regorafenib or a pl…

This study tested a drug called avelumab in 19 children and young adults (ages 12-49) whose osteosarcoma (a type of bone cancer) had come back or was not responding to standard treatments. The goal was to see if avelumab could shrink tumors or stop the cancer from growing for at …

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

This study tested a drug called tazemetostat in 20 children whose cancers had come back or weren't responding to treatment. The children had specific gene changes (EZH2, SMARCB1, or SMARCA4) in their tumors. The goal was to see if the drug could shrink or slow the growth of these…

This study tested a combination of two chemotherapy drugs, nab-paclitaxel and gemcitabine, in 59 teenagers and young adults whose sarcoma (a type of bone or soft tissue cancer) had returned or not responded to standard treatment. The main goals were to see if the drug combo could…

This study tested a drug called palbociclib in 23 children and young adults (ages 1–21) whose cancers had come back or didn't respond to treatment. The drug works by blocking proteins that help cancer cells grow. The goal was to see if it could shrink tumors or slow the disease i…

This early-stage trial tested a new drug called azenosertib (ZN-c3) combined with the chemotherapy gemcitabine in 31 people aged 12 and older with osteosarcoma that had relapsed or stopped responding to treatment. The goal was to see if the combination is safe and whether it can …

This study tested an experimental drug called ENV-101 (taladegib) in 20 adults with advanced solid tumors that have a specific genetic mutation (PTCH1 loss-of-function). The drug works by blocking a growth pathway in cancer cells. Researchers measured how many patients' tumors sh…

This study tested the safety and effectiveness of the drug abemaciclib combined with other cancer medicines in 47 children and young adults whose solid tumors (including neuroblastoma) had stopped responding to standard treatments. The goal was to find the best dose and see if th…

This early-phase trial tested a new approach for osteosarcoma (bone cancer) in 10 patients aged 12-40. The treatment combined standard chemotherapy with a targeted drug (Endostar) and cisplatin delivered directly into the artery supplying the tumor. The goal was to see if this me…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and cyclophosphamide (a chemotherapy)—in 129 people with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the combination could shrink tumors or stop them fro…

This study tested a drug called ADI-PEG 20 combined with two chemotherapy drugs (gemcitabine and docetaxel) in 98 people with soft tissue sarcoma, osteosarcoma, Ewing's sarcoma, or small cell lung cancer. The goal was to see if the combination could slow cancer growth better than…

This early-phase study tests whether glucarpidase can lower the toxic side effects of high-dose methotrexate in adults with osteosarcoma, a type of bone cancer. The goal is to help patients complete their planned chemotherapy doses and spend less time in the hospital. About 12 pa…

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This study looked at 3000 cancer patients to see which treatments work best for preventing dangerously low white blood cell counts after chemotherapy. It compared different approaches to see how well they prevent infections and improve quality of life. The goal is to give doctors…

This study looked at 92 adults who had chemotherapy for bone tumors (osteosarcoma or Ewing sarcoma) as children or teenagers. Researchers used surveys to measure thinking, memory, and concentration problems years after treatment. The goal was to understand which patients are most…

This study followed 100 people who had surgery to remove bone or soft tissue tumors in their leg or pelvis. Researchers measured how independent they became in daily activities and how well their joints moved during the first six months after surgery. The goal was simply to descr…

This study tested whether a special MRI technique called diffusion-weighted MRI (DWI-MRI) can safely and accurately stage sarcomas in children without using radiation. 98 children with bone or soft-tissue sarcomas received DWI-MRI scans, and researchers compared the results to st…

This study looked back at the medical records of 545 patients with bone tumors that had spread (metastatic). The goal was to see how these patients were treated in real life and what their outcomes were. The study focused on three types of bone tumors: osteosarcoma, Ewing sarcoma…

This study created a registry and biobank for people with osteosarcoma, a rare bone cancer, and their family members. Researchers collected genetic samples from 362 participants to compare genes of those with and without the disease. The goal is to better understand what causes o…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This study tested whether analyzing the DNA and RNA of a child's tumor could help doctors choose personalized treatments. It included 186 children with relapsed or hard-to-treat cancers like neuroblastoma and brain tumors. The goal was to see if this approach was feasible and saf…

Researchers used machine learning to analyze electronic health records from 700 patients with osteosarcoma or Ewing's sarcoma. The goal was to find patterns in survival and other outcomes. No new treatment was tested; instead, the study aimed to learn from existing data to potent…

This study looked back at medical records of 91 children who had a malignant bone tumor removed from their leg and then had the bone rebuilt using one of three techniques: induced membrane, vascularized fibula, or vascularized fibula plus a bone graft. The goal was to compare how…