Osteonecrosis
MONDO:0005380A none disease characterized by death of bone tissue due to a lack of blood supply.
Also known as: bone necrosis, ischaemic bone disease, ischemic bone disease, osteonecrosis
224 clinical trials for this condition and its sub-types, 59 tagged with Osteonecrosis itself.
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Sub-types of Osteonecrosis
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Avascular necrosis 80 trials · 141 incl. sub-types
3 sub-types
- Primary avascular necrosis 0 trials · 39 incl. sub-types Sub-types →
- Secondary avascular necrosis 1 trial · 38 incl. sub-types Sub-types →
- Dysbaric osteonecrosis 0 trials
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Osteonecrosis of genetic origin 0 trials · 102 incl. sub-types
12 sub-types
- Familial avascular necrosis of femoral head 20 trials · 39 incl. sub-types Sub-types →
- Scheuermann disease 24 trials
- Osteochondritis dissecans 20 trials
- Gaucher disease type I 12 trials
- Legg-Calve-Perthes disease 9 trials
- Dihydropyrimidine dehydrogenase deficiency 3 trials
- Epiphysiolysis of the hip 3 trials
- Hereditary antithrombin deficiency 3 trials
- Thiemann disease, familial form 0 trials
- Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency 0 trials
- Pseudohypoparathyroidism type 1C 0 trials
- Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 0 trials
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Osteochondrosis 8 trials · 46 incl. sub-types
11 sub-types
- Scheuermann disease 24 trials
- Legg-Calve-Perthes disease 9 trials
- Osgood-Schlatter disease 5 trials
- Dihydropyrimidine dehydrogenase deficiency 3 trials
- Kienbock disease 1 trial
- Osteochondritis of tarsal/metatarsal bone 1 trial
- Freiberg disease 0 trials
- Sinding-Larsen-Johansson disease 0 trials
- Thiemann disease, familial form 0 trials
- Medial condensing osteitis of the clavicle 0 trials
- Panner disease 0 trials
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Osteoradionecrosis 14 trials · 15 incl. sub-types
1 sub-type
- Osteoradionecrosis of the mandible 5 trials
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Dieterich disease 1 trial
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Kummell disease 1 trial
Most studied deeper sub-types
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New Stem-Free shoulder implant shows promise in european study
Disease control CompletedThis study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New shoulder implant shows promise in early study
Disease control CompletedThis study tested a new shoulder implant called the Catalyst CSR System in 87 people with shoulder arthritis or bone damage. The implant is designed to preserve more natural bone than traditional replacements. Researchers measured pain, movement, and implant safety over two years…
Sponsor: Catalyst OrthoScience • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Hip implant passes 10-Year test
Disease control CompletedThis study looked at how well a specific hip replacement system (the Allofit IT Shell with Longevity Liners) works over 10 years. 197 people with hip problems like arthritis or bone death received the implant. The main goal was to see how many implants were still in place without…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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AI trained to spot dead jawbone on routine dental X-Rays
Diagnosis CompletedResearchers at Izmir Katip Celebi University are testing a deep learning model called UNet to automatically outline bone sequestra, pieces of dead jawbone, on panoramic dental X-rays. The study uses 120 anonymized X-rays with 134 marked lesions from patients who had radiotherapy,…
Sponsor: Izmir Katip Celebi University • Aim: Diagnosis
Last updated Sep 11, 2026 00:00 UTC
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Blood pressure drug may shield young cancer patients from crippling bone disease
Prevention CompletedThis study tested whether keeping blood pressure in a lower, healthier range could prevent a painful bone condition called osteonecrosis in children and young adults being treated for leukemia. Fifty-one participants were randomly assigned to either intensive or standard blood pr…
Phase 2 • Sponsor: St. Jude Children's Research Hospital • Aim: Prevention
Last updated Jul 22, 2026 00:00 UTC
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New drug RAB001 takes first step: safety check in healthy volunteers
Knowledge-focused CompletedThis early-stage study tested the safety and tolerability of a new drug called RAB001 in 16 healthy adults. Researchers gave single and multiple injections at two dose levels to see how the body handles the drug and if it causes side effects. This is a first step before testing t…
Phase 1 • Sponsor: ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Knee surgery drain debate: new study compares blood loss with and without drain
Knowledge-focused CompletedThis study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether patients need a blood transfusion. 102 patients were randomly assigned to get a drain or not. The goal is to see if drains help or hurt in terms of blood loss…
Sponsor: Shifa International Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Hip implant performance tracked in 162 patients
Knowledge-focused CompletedThis study followed 162 people who received a G7 hip cup system during hip replacement surgery. Researchers measured pain, function, and hip movement using standard scores. The goal was to see how the device performs in everyday patients with arthritis or other joint problems.
Sponsor: Zimmer Biomet • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Hip implant showdown: which stem saves more bone?
Knowledge-focused CompletedThis study looked at 40 people who had a total hip replacement through a small incision in the front of the hip. Researchers compared two types of metal stems (AMIStem and Quadra) to see how bone density around the implant changed one year after surgery. The goal was to find out …
Sponsor: Medacta International SA • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC