Osteogenesis imperfecta type 3

MONDO:0009804

Osteogenesis imperfecta type III is a severe type of osteogenesis imperfecta (OI), a genetic disorder characterized by increased bone fragility, low bone mass and susceptibility to bone fractures. The main signs of type III include very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta (DI).

Also known as: OI type 3, OI3, osteogenesis imperfecta type 3, osteogenesis imperfecta type III, progressive deforming osteogenesis imperfecta, severe osteogenesis imperfecta, OI type III, OI, type 3

9 clinical trials for this condition and its sub-types, 9 tagged with Osteogenesis imperfecta type 3 itself.

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Where it sits in the disease tree

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Part of

↑ Osteogenesis imperfecta and a reduction of bone mineral density. (307)

Including sub-types (9) Tagged with Osteogenesis imperfecta type 3 (9)

Trials to join now! 2 Not yet recruiting 1 Not yet finished but already full! 4 Completed 2

Could donor stem cells help kids with brittle bones grow taller and stronger?

Disease control Not yet recruiting

This early-phase trial tests whether infusions of donor bone marrow stem cells (MSCs) are safe and can improve growth and bone health in 12 children aged 3–10 with severe osteogenesis imperfecta type 3. The study will monitor side effects, growth rates, fracture healing, and bone…

Phase 1/2 • Sponsor: Emory University • Aim: Disease control

Last updated Jun 27, 2026 12:30 UTC

Osteogenesis imperfecta type 3

Where it sits in the disease tree

Could donor stem cells help kids with brittle bones grow taller and stronger?