Obstructive hydrocephalus
MONDO:0001896An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of an obstruction at any location within the ventricular system that prevents cerebrospinal fluid flowing into the subarachnoid space.
Also known as: non-communicating hydrocephalus
8 clinical trials for this condition and its sub-types, 6 tagged with Obstructive hydrocephalus itself.
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Can a One-Time brain surgery free children from a lifetime of shunts?
Disease control Not yet recruitingThis trial tests whether a combined surgical procedure — endoscopic third ventriculostomy plus choroid plexus cauterization (ETV+CPC) — can effectively treat hydrocephalus in children without needing a permanent shunt. The surgery aims to create a new fluid pathway and reduce flu…
Sponsor: Assiut University • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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Brain bleed breakthrough? new drug could stop fluid buildup without surgery
Disease control Not yet recruitingThis early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial wil…
Phase 1/2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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Could a sprinkle of antibiotic powder stop brain shunt infections in kids?
Prevention Not yet recruitingThis study tests whether applying vancomycin powder directly into the surgical wound during shunt placement can prevent infections in children with hydrocephalus. About 164 children will be randomly assigned to receive either standard care or standard care plus the powder. The go…
Phase 4 • Sponsor: Assiut University • Aim: Prevention
Last updated Jun 27, 2026 12:23 UTC
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New MRI scans could transform care for preterm babies with brain bleeds
Knowledge-focused Not yet recruitingThis study will use advanced MRI scans to better understand brain injury in premature babies who have bleeding in the brain's fluid spaces. About 450 babies in England suffer from severe bleeds each year, which can lead to fluid buildup and long-term disability. Researchers will …
Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC