Obesity due to congenital leptin deficiency

MONDO:0013991

Congenital leptin deficiency is a form of monogenic obesity characterized by severe early-onset obesity and marked hyperphagia.

Also known as: Congenital Leptin Deficiency, obesity, morbid, due to leptin deficiency, LEPD, leptin deficiency or dysfunction, obesity, morbid, nonsyndromic 1

81 clinical trials for this condition and its sub-types, 1 tagged with Obesity due to congenital leptin deficiency itself.

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Where it sits in the disease tree

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↑ Congenital hypogonadotropic hypogonadism (83) ↑ Inherited obesity (9)

Including sub-types (81) Tagged with Obesity due to congenital leptin deficiency (1)

Trials to join now! 1

New drug hopes to curb rare genetic obesity

Disease control Recruiting now

This study tests an experimental drug called mibavademab in people with a rare form of obesity caused by a faulty leptin gene. The drug aims to help control hunger and body weight. Only 4 participants will be enrolled to see how well it works and if it is safe.

Phase 3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control

Last updated Jun 27, 2026 11:00 UTC

Obesity due to congenital leptin deficiency

Where it sits in the disease tree

New drug hopes to curb rare genetic obesity