Newborn respiratory distress syndrome

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This trial compares two noninvasive breathing support methods—heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP)—in premature infants (born at 28-34 weeks) with moderate respiratory distress syndrome. The goal is to see which …

This study tested whether a new device called Mixsafe works as well as the standard Neopuff device for helping newborns breathe. 107 babies who needed breathing support at birth took part. The goal was to see if Mixsafe could be a safe and effective alternative for hospitals.

This study looked at 180 premature babies born between 24 and 30 weeks to see if giving lung medication (surfactant) through a thin tube (LISA method) could reduce the need for a breathing tube in the first three days of life, compared to standard CPAP alone. The goal was to find…

Researchers are testing whether a quick lung ultrasound and a blood test for the protein ANGPTL4 can predict which late preterm and full-term newborns with breathing trouble will need NICU admission. The study includes 80 newborns born at 34 weeks or later who show signs of respi…

This study compared two groups of women having planned C-sections: one group had the surgery at 38 weeks after receiving two steroid shots (betamethasone) to speed up the baby's lung development, while the other group had the surgery at 39 weeks without steroids. The goal was to …

Researchers compare two ways of giving nasal breathing support to preterm infants born before 32 weeks of pregnancy. One method delivers puffs of air on a fixed rhythm, while the other syncs each puff to the baby's own breathing using a flow sensor. The trial tracks how often bab…

This study tested two non-invasive breathing machines in 49 newborns (born at 33 weeks or later) with respiratory distress. One machine is the standard nasal CPAP, and the other is a newer device called nasal high frequency percussive ventilation. Researchers measured brain oxyge…

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested whether giving two medicines (atropine and fentanyl) before a less invasive breathing treatment helps preterm babies have fewer dangerous drops in heart rate and oxygen levels. Fifty-eight babies born at 29 weeks or later took part. The goal is to see if premedi…

This study looked at whether a narrower oxygen saturation target range helps an automated oxygen control system work better for very low birth weight infants on breathing support. Eleven babies were randomly assigned to either a 3% or a shifted 3% target range. The goal was to se…

This study looked at whether a lung ultrasound score can help doctors decide when to safely remove a breathing tube from newborn babies with breathing problems. 71 infants in the NICU had an ultrasound before and after their breathing tube was removed. The goal was to see if the …

This study looked at how changing the speed at which a ventilator reaches its target pressure affects breathing in 17 newborns on breathing support. The researchers tested different settings and measured changes in airway pressure and gas exchange. The goal was to find out if thi…

This study looked at 127 pregnant women who received a steroid called betamethasone to help prevent lung problems in their premature babies. Researchers measured how much of the drug reached the baby and whether it reduced the risk or severity of hyaline membrane disease, a serio…

This study tested a new way to measure pain in preterm infants during a procedure called LISA, where surfactant is given to help them breathe. Researchers used skin conductance, which tracks nerve signals, and compared it to a standard pain scale. The goal was to see if this meth…

This pilot study tested two ways to help premature babies breathe right after birth: volume-targeted ventilation (giving a set amount of air) versus pressure-targeted ventilation (giving air at a set pressure). The study included 52 infants born between 23 and 28 weeks of pregnan…

This study followed 397 premature babies (under 32 weeks) who were given non-invasive breathing support. Researchers looked for early clues, like how much extra oxygen the babies needed, to predict which ones would later need a breathing tube. The goal is to help doctors decide e…