Neuromuscular disease
MONDO:0019056Any disease that impairs the functioning of the muscles, either directly, being pathologies of the voluntary muscle, or indirectly, being pathologies of nerves or neuromuscular junctions
Also known as: nerve and muscle disorder, neuromuscular disease
2353 clinical trials for this condition and its sub-types, 112 tagged with Neuromuscular disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Neuromuscular disease
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Peripheral neuropathy 93 trials · 1,473 incl. sub-types
30 sub-types
- Hereditary peripheral neuropathy 6 trials · 479 incl. sub-types Sub-types →
- Neuralgia 238 trials · 384 incl. sub-types Sub-types →
- Nerve compression syndrome 24 trials · 207 incl. sub-types Sub-types →
- Diabetic neuropathy 182 trials · 193 incl. sub-types Sub-types →
- Chemotherapy-induced neuropathy 171 trials
- Polyneuropathy 32 trials · 133 incl. sub-types Sub-types →
- Mononeuropathy 4 trials · 112 incl. sub-types Sub-types →
- Acquired peripheral neuropathy 0 trials · 95 incl. sub-types Sub-types →
- Nerve plexus disorder 0 trials · 75 incl. sub-types Sub-types →
- Sensory peripheral neuropathy 4 trials · 58 incl. sub-types Sub-types →
- Traumatic neuropathy 55 trials
- Neuritis 18 trials · 29 incl. sub-types Sub-types →
- Peripheral nerve lesion 1 trial · 12 incl. sub-types Sub-types →
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Chronic idiopathic neuropathy 5 trials
- Axonal neuropathy 1 trial · 4 incl. sub-types Sub-types →
- Neuropathy, small fiber 4 trials
- Infectious neuropathy 2 trials
- Vasculitic neuropathy 2 trials
- Autoimmune neuropathy 1 trial
- Idiopathic small fibers neuropathy 1 trial
- Ischemic neuropathy 1 trial
- Motor peripheral neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Radiation-induced neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Sarcoid neuropathy 1 trial
- Neuropathy in cryoglobulinemia 0 trials
- Neuropathy in endocrine disorder 0 trials
- Paraproteinemia-associated neuropathy 0 trials
- Uremic neuropathy 0 trials
- Vitamin deficiency related neuropathy 0 trials
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Hereditary neuromuscular disease 3 trials · 935 incl. sub-types
22 sub-types
- Hereditary peripheral neuropathy 6 trials · 479 incl. sub-types Sub-types →
- Muscular dystrophy 74 trials · 290 incl. sub-types Sub-types →
- Hereditary motor neuron disease 1 trial · 169 incl. sub-types Sub-types →
- Hereditary spastic paraplegia 27 trials · 33 incl. sub-types Sub-types →
- Benign paroxysmal positional vertigo 18 trials
- Meniere disease 16 trials Sub-types →
- RYR1-related myopathy 5 trials · 6 incl. sub-types Sub-types →
- Congenital myasthenic syndrome 6 trials Sub-types →
- Malignant hyperthermia of anesthesia 5 trials
- SCN4A-related channelopathy 1 trial · 2 incl. sub-types Sub-types →
- Early-onset myopathy with fatal cardiomyopathy 1 trial
- Andersen-Tawil syndrome 0 trials
- CNGB3-related retinopathy 0 trials Sub-types →
- KY-related neuromyopathy 0 trials Sub-types →
- Morimoto-Ryu-Malicdan neuromuscular syndrome 0 trials
- X-linked recessive mitochondrial myopathy 0 trials
- Myofibrillar myopathy 1 0 trials
- Myotonia congenita, autosomal dominant 0 trials
- Myotonia congenita, autosomal recessive 0 trials
- Neuromuscular disorder, congenital, with dysmorphic facies 0 trials
- Periodic paralysis with later-onset distal motor neuropathy 0 trials
- Vertigo, benign recurrent, 1 0 trials
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Motor neuron disorder 70 trials · 510 incl. sub-types
4 sub-types
- Amyotrophic lateral sclerosis 331 trials · 345 incl. sub-types Sub-types →
- Hereditary motor neuron disease 1 trial · 169 incl. sub-types Sub-types →
- Acquired motor neuron disease 0 trials · 39 incl. sub-types Sub-types →
- Madras motor neuron disease 0 trials
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Vestibular disorder 64 trials · 92 incl. sub-types
1 sub-type
- Peripheral vertigo 2 trials · 34 incl. sub-types Sub-types →
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Muscular channelopathy 0 trials · 19 incl. sub-types
12 sub-types
- Thomsen and Becker disease 9 trials Sub-types →
- RYR1-related myopathy 5 trials · 6 incl. sub-types Sub-types →
- Malignant hyperthermia of anesthesia 5 trials
- SCN4A-related channelopathy 1 trial · 2 incl. sub-types Sub-types →
- Andersen-Tawil syndrome 0 trials
- CNGB3-related retinopathy 0 trials Sub-types →
- Isaac syndrome 0 trials
- Morvan syndrome 0 trials
- Neurological muscular channelopathy due to a genetic calcium channel defect 0 trials
- Neurological muscular channelopathy due to a genetic chloride channel defect 0 trials
- Neurological muscular channelopathy due to a genetic potassium channel defect 0 trials
- Neurological muscular channelopathy due to a genetic sodium channel defect 0 trials
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Atrophic muscular disease 7 trials
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Neuromuscular junction disease 1 trial · 7 incl. sub-types
1 sub-type
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Akinetopsia 0 trials
Most studied deeper sub-types
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Experimental drug losmapimod tested in rare muscle disease – early hopes, but trial cut short
Disease control Stopped earlyThis study tested an experimental drug called losmapimod in 14 adults with FSHD1, a rare genetic condition that causes progressive muscle weakness. The main goal was to check safety and tolerability, and to see if the drug affects certain biological markers. The trial was termina…
Phase 2 • Sponsor: Fulcrum Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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New drug trial for duchenne MD halted early – what we know
Disease control Stopped earlyThis phase 2 study tested a drug called PGN-EDO51 in 7 people with Duchenne muscular dystrophy whose genetic mutation can be corrected by skipping exon 51. The drug was given by IV infusion to see if it is safe and tolerable. The trial was terminated, so results are limited.
Phase 2 • Sponsor: PepGen Inc • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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FSHD drug trial halted midway: what happened?
Disease control Stopped earlyThis study tested a drug called losmapimod for people with a rare muscle-weakening disease called FSHD. The goal was to see if the drug could slow muscle loss and improve arm function over 48 weeks. About 260 adults with FSHD were randomly assigned to receive either losmapimod or…
Phase 3 • Sponsor: Fulcrum Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Experimental drug losmapimod tested for rare muscle disease
Disease control Stopped earlyThis phase 2 trial tested the drug losmapimod in 76 adults with FSHD, a genetic condition that causes progressive muscle weakness. Participants took either losmapimod or a placebo for 48 weeks to see if the drug was safe and could help control the disease. The study was terminate…
Phase 2 • Sponsor: Fulcrum Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Robotic glove aims to give weak hands a grip on daily life
Symptom relief Stopped earlyThis study tested a soft-robotic glove called Carbonhand in 6 people with hand weakness due to aging or neuromuscular disease. The glove supports finger movement to help with daily tasks. Researchers measured how the glove affected movement, pain, and fatigue during strenuous act…
Sponsor: Roessingh Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC