Neoplasm of esophagus

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus chemotherapy, or a stand…

This study tests new experimental drugs combined with standard chemotherapy and immunotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery or has spread. About 160 participants will receive the combination to …

This trial compares two liquids—hyaluronic acid and hydroxyethylamide—used to lift early-stage esophageal tumors before endoscopic removal. Doctors inject one of these solutions under the cancer to create a cushion, making it safer and easier to cut out. The study measures how mu…

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This early-phase trial tests a new drug, UCB4594, in people with advanced solid tumors that haven't responded to standard treatments. The drug is a monoclonal antibody that targets a protein called HLA-G on cancer cells, potentially helping the immune system attack them. The stud…

This study is testing whether a procedure called gastric preconditioning—done before esophageal cancer surgery—can lower the risk of a serious complication called an anastomotic leak. The procedure uses a tiny tube to redirect blood flow in the stomach, which may help the surgica…

This study tests whether adding omega-3 fatty acids (EPA and DHA) to standard PD-1 inhibitor therapy helps patients with advanced esophageal cancer. About 142 adults will receive either omega-3 or placebo drops daily for 6 months alongside their cancer treatment. The main goal is…

This trial compares two types of esophageal stents—fully covered and partially covered—for people with advanced esophageal cancer who have trouble swallowing. The goal is to see which stent requires fewer repeat procedures and has fewer complications. Participants receive one of …

This study tests a personalized rehabilitation program for people recovering from surgery for esophageal or gastric cancer. Participants will receive a structured assessment of their physical, psychological, and social needs, followed by evidence-based support. The goal is to imp…

This study tests a new device called the Speedboat™ Ultraslim, a bipolar radiofrequency knife, for removing precancerous growths in the esophagus. Researchers want to see if it works well and is safe compared to standard tools. The trial will involve 50 adults at two medical cent…

This study tests a six-week program of morning bright light exposure combined with moderate walking for people with lung or esophageal cancer. The goal is to see if it can improve sleep-wake rhythms, reduce physical and emotional symptoms, and boost quality of life. Two hundred p…

This research study is investigating how genetics and environmental factors contribute to the development of Barrett's esophagus and esophageal adenocarcinoma, a type of cancer. Researchers will collect samples from the esophagus using a non-endoscopic balloon capsule device, whi…

This study is collecting survey responses from 1,000 people who have had or will have surgery on their esophagus. The goal is to validate new questionnaires that measure recovery and symptoms. The information will help doctors set expected recovery scores and improve treatment pl…

This study compares two surgical procedures for patients with a specific type of cancer where the stomach meets the esophagus. Half of the 120 participants will have only the upper part of the stomach removed (proximal gastrectomy), while the other half will have the entire stoma…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study looks back at medical records of 2000 adults who had endoscopic removal of cancerous or precancerous growths in the esophagus, stomach, duodenum, colon, or rectum. The goal is to compare different removal methods to see which works best and has the fewest complications…