Neonatal ichthyosis-sclerosing cholangitis syndrome

MONDO:0011874

Neonatal ichthyosis-sclerosing cholangitis (NISCH syndrome) is a very rare complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, ichthyosis and sclerosing cholangitis.

Also known as: IHSC, NISCH syndrome, ichthyosis-hypotrichosis-sclerosing cholangitis syndrome, neonatal ichthyosis-sclerosing cholangitis syndrome, ILVASC, Ilvasc, Nisch syndrome, ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis

6 clinical trials for this condition and its sub-types, 0 tagged with Neonatal ichthyosis-sclerosing cholangitis syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Syndromic disease (7158) ↑ Sclerosing cholangitis (57) ↑ Inherited ichthyosis (33)

Including sub-types (6) Tagged with Neonatal ichthyosis-sclerosing cholangitis syndrome (0)

Trials to join now! 2 Not yet finished but already full! 1 Completed 2 Terminated 1

Promising ichthyosis drug trial stalls after just 5 patients

Disease control Stopped early

This study tested a drug called imsidolimab (ANB019) in people with ichthyosis, a condition that causes dry, scaly, and red skin. The trial aimed to see if the drug could improve skin symptoms compared to a placebo. However, the study was stopped early and only enrolled 5 partici…

Phase 2 • Sponsor: Vanda Pharmaceuticals • Aim: Disease control

Last updated Jun 26, 2026 17:50 UTC

Neonatal ichthyosis-sclerosing cholangitis syndrome

Where it sits in the disease tree

Promising ichthyosis drug trial stalls after just 5 patients