Myelin oligodendrocyte glycoprotein antibody-associated disease
MONDO:1040024A demyelinating disease of the central nervous system characterized by the presence of a demyelinating event (optic neuritis, myelitis, acute/multiphasic encephalomyelitis, cerebral or polyfocal deficits, brainstem or cerebellar deficits, and/or cerebral cortical encephalitis), a positive myelin oligodendrocyte glycorotein-IgG test, and exclusion of an alternative diagnosis like MS.
24 clinical trials for this condition and its sub-types, 22 tagged with Myelin oligodendrocyte glycoprotein antibody-associated disease itself.
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Browse by category →Sub-types of Myelin oligodendrocyte glycoprotein antibody-associated disease
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Can CRISPR-Edited cells stop autoimmune attacks on the brain?
Cure Not yet recruitingThis trial tests a therapy called CTX112 in adults with severe neurologic autoimmune diseases, including progressive multiple sclerosis, neuromyelitis optica, and stiff-person syndrome. CTX112 uses donor T cells edited with CRISPR to target and deplete B cells, which are thought …
Phase 1/2 • Sponsor: CRISPR Therapeutics • Aim: Cure
Last updated Sep 11, 2026 00:00 UTC
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Genetic clues may forecast multiple sclerosis after vision loss
Knowledge-focused Not yet recruitingThis observational study looks at whether combining genetic information with standard clinical data can better predict who will develop multiple sclerosis after a first episode of optic neuritis (inflammation of the optic nerve). Researchers will follow 180 people aged 16 and old…
Sponsor: King's College London • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC
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MOGAD mystery: do headaches signal more?
Knowledge-focused Not yet recruitingThis study aims to find out how often headaches happen in people with MOGAD, a rare disease that affects the brain and nerves. Researchers will look at the medical records of 25 adults and also follow them forward in time to describe headache patterns. The goal is to better under…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Massive Real-World study to track brain and nerve autoimmune disorders
Knowledge-focused Not yet recruitingThis study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday medical practice. Researchers will measure disabili…
Sponsor: Tongji Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC