Myalgic encephalomeyelitis/chronic fatigue syndrome

This Phase 2 trial tests whether N-Acetylcysteine (NAC), an antioxidant, can help people with ME/CFS (chronic fatigue syndrome). Researchers will give 95 participants different doses of NAC or a placebo for four weeks, then measure brain glutathione levels and markers of oxidativ…

This study tests an experimental drug called Ampligen (rintatolimod) in people with severe chronic fatigue syndrome (CFS). Participants receive twice-weekly IV infusions over several months. The goal is to see if the drug can ease symptoms and improve quality of life for those wh…

Functional somatic disorders cause persistent physical symptoms that doctors cannot explain by other diseases. The DISTRESS trial evaluates a new clinic where internal medicine doctors, trained to recognize these disorders, examine patients and provide guidance to their general p…

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This trial tests whether a small device that stimulates the vagus nerve through the ear can improve quality of life for people with long COVID who also meet the criteria for ME/CFS (chronic fatigue syndrome). Participants will use the device daily for six weeks, and researchers w…

This study looks at whether low-dose rapamycin can reduce symptoms and improve quality of life in people with ME/CFS or Long-COVID. About 150 participants will take the drug as prescribed by their doctor and complete surveys and blood tests over time. The goal is to see if the dr…

This study compares a 12-week tele-rehabilitation program using mindful and conscious movement (like adapted yoga and breathing exercises) to conventional low-intensity exercise and usual care for people with chronic fatigue syndrome or post-COVID syndrome. The goal is to see if …

This study tests whether the drug vericiguat, already approved for heart failure, can improve physical function and reduce fatigue in people aged 18-50 with post-COVID syndrome. About 104 participants will receive either vericiguat or a placebo for 10 weeks, then be followed for …

This study tests whether a traditional Chinese herbal paste called Yiqi Fuyuan Paste can reduce fatigue in adults with Chronic Fatigue Syndrome (CFS). Eighty participants will take either the paste or a placebo daily for two months. Researchers will measure fatigue levels and che…

This study tests a new, team-based rehabilitation program for 125 working-age adults with persistent physical symptoms and chronic fatigue. The program includes doctors, therapists, and counselors who work together to help patients manage their symptoms and improve daily function…

This study tests whether a gentle electrical brain stimulation device, used at home under remote supervision, can help reduce fatigue in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Twenty participants will use the device for 20 minutes each weekday ov…

This study aims to better understand fatigue by comparing people who have felt tired for more than a month with those who are not fatigued. Researchers will use questionnaires, physical tests, and optional brain scans to identify different types of fatigue. The goal is to gather …

This Johns Hopkins study looks at whether a leaky blood-brain barrier and immune changes contribute to cognitive problems in people with ME/CFS (chronic fatigue syndrome), both those who got sick before the pandemic and those who developed it after COVID-19. Researchers will use …

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. Th…

This pilot study looks at whether light, self-paced swimming is a tolerable activity for people with ME/CFS and related conditions like Long COVID and fibromyalgia. Participants will swim for 15-30 minutes at their own pace and track symptoms and heart rate variability using an a…

This study is for people with Long COVID, Lyme disease, or ME/CFS (chronic fatigue syndrome). Researchers want to see if a special blood test can find problems with T-cells, which are part of the immune system. Participants will give blood samples and fill out symptom questionnai…