Multiple organ dysfunction syndrome
MONDO:0043726The development of potentially reversible physiologic derangement involving two or more organ systems not involved in the disorder that resulted in intensive care unit (ICU) admission, and arising in the wake of a potentially life-threatening physiologic insult.
Also known as: multiorgan failure, multiple organ dysfunction syndrome, multiple organ failure, multiple organ system failure, MODS, failure, multiple organ, multi-organ failure, multiple organ failures
50 clinical trials for this condition and its sub-types, 50 tagged with Multiple organ dysfunction syndrome itself.
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Blood filter during heart bypass may prevent organ damage, but trial stopped early
Disease control Stopped earlyThis study tested a device called Efferon LPS that filters blood during heart surgery when a heart-lung machine is used. The goal was to see if it could prevent multiple organ failure, especially kidney damage. Only 14 people took part before the study was stopped, so the results…
Sponsor: Efferon JSC • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Epilepsy drug may protect organs during heart surgery — trial tests the idea
Prevention Stopped earlyThis trial tests whether sodium valproate, a drug used for epilepsy, can reduce damage to the heart and kidneys in adults undergoing heart surgery with a heart-lung machine. Participants receive the drug for one to six weeks before their operation, and researchers measure organ i…
Phase 1/2 • Sponsor: University of Leicester • Aim: Prevention
Last updated Aug 19, 2026 00:00 UTC