Multicentric Castleman disease
MONDO:0019754Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.
Also known as: HHV-8-associated multicentric Castleman disease, Human herpesvirus-8-associated multicentric Castleman disease, MCD, multicentric Angiofollicular lymphoid hyperplasia, multicentric Castleman's disease, idiopathic multicentric Castleman's disease, multicentric plasma cell variant of Castleman's disease
1487 clinical trials for this condition and its sub-types, 13 tagged with Multicentric Castleman disease itself.
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New hope for rare cancers: daratumumab trial targets Hard-to-Treat lymphomas
Disease control Recruiting nowThis phase 2 trial tests the drug daratumumab in 28 adults with three rare and aggressive blood cancers: primary effusion lymphoma, plasmablastic lymphoma, and multicentric Castleman disease. Participants must have failed standard therapy or be unable to receive it. Daratumumab i…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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New drug trial targets deadly inflammation in HIV patients
Disease control Recruiting nowThis study tests a drug called pacritinib in people with HIV who have two rare conditions caused by the Kaposi sarcoma herpesvirus (KSHV): KSHV-associated multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). These conditions cause severe, life-thre…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Can a tiny device speed up cancer diagnosis for people with HIV?
Diagnosis Recruiting nowThis study tests new diagnostic approaches for lymphoma and multicentric Castleman disease in people living with HIV who have swollen lymph nodes. Researchers will compare standard biopsies with fine needle aspiration and a new nucleic acid amplification device called TINY. The g…
Sponsor: Indiana University • Aim: Diagnosis
Last updated Aug 30, 2026 00:00 UTC
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Scientists seek tissue samples to unlock HIV and cancer mysteries
Knowledge-focused Recruiting nowThis study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists hunt for genetic clues in Virus-Linked cancers
Knowledge-focused Recruiting nowThis study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Researchers launch long-term observation study for rare KSHV-linked disease
Knowledge-focused Recruiting nowThis study follows 195 adults with KSHV-associated multicentric Castleman's disease (MCD) to better understand how the disease progresses and responds to treatments. Participants receive standard care and regular check-ups over several years. The goal is to improve future treatme…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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Scientists seek tissue samples to unlock HIV-Cancer mysteries
Knowledge-focused Recruiting nowThis study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…
Sponsor: AIDS Malignancy Consortium • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:01 UTC