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Mitochondrial respiratory chain complex deficiency
MONDO:0000066A mitochondrial energy metabolism disorder where respiratory complex (I–V) is dysfunctional, typically due to mutations in genes encoding that specific complex’s proteins or assembly factors.
Also known as: isolated oxidative phosphorylation complex disorder, mitochondrial complex deficiency
16 clinical trials for this condition and its sub-types, 4 tagged with Mitochondrial respiratory chain complex deficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Mitochondrial respiratory chain complex deficiency
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Mitochondrial complex I deficiency 2 trials
2 sub-types
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22 sub-types
- COX deficiency, benign infantile mitochondrial myopathy 0 trials
- Mitochondrial complex 4 deficiency, nuclear type 25 0 trials
- Mitochondrial complex IV deficiency, nuclear type 1 0 trials
- Mitochondrial complex IV deficiency, nuclear type 10 0 trials
- Mitochondrial complex IV deficiency, nuclear type 11 0 trials
- Mitochondrial complex IV deficiency, nuclear type 12 0 trials
- Mitochondrial complex IV deficiency, nuclear type 14 0 trials
- Mitochondrial complex IV deficiency, nuclear type 15 0 trials
- Mitochondrial complex IV deficiency, nuclear type 16 0 trials
- Mitochondrial complex IV deficiency, nuclear type 17 0 trials
- Mitochondrial complex IV deficiency, nuclear type 18 0 trials
- Mitochondrial complex IV deficiency, nuclear type 19 0 trials
- Mitochondrial complex IV deficiency, nuclear type 20 0 trials
- Mitochondrial complex IV deficiency, nuclear type 21 0 trials
- Mitochondrial complex IV deficiency, nuclear type 22 0 trials
- Mitochondrial complex IV deficiency, nuclear type 23 0 trials
- Mitochondrial complex IV deficiency, nuclear type 24 0 trials
- Mitochondrial complex IV deficiency, nuclear type 3 0 trials
- Mitochondrial complex IV deficiency, nuclear type 4 0 trials
- Mitochondrial complex IV deficiency, nuclear type 7 0 trials
- Mitochondrial complex IV deficiency, nuclear type 8 0 trials
- Pancreatic insufficiency-anemia-hyperostosis syndrome 0 trials
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SDHC-related Mitochondrial Disease 0 trials
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Mitochondrial complex III deficiency 0 trials
1 sub-type
Most studied deeper sub-types
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New drug shows promise for rare energy disorder
Disease control CompletedThis study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…
Phase 2 • Sponsor: Omeicos Therapeutics GmbH • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Long-Term safety of mitochondrial drug confirmed in 101 patients
Disease control CompletedThis study looked at the safety of vatiquinone in 101 people with inherited mitochondrial disease who had already taken the drug in a previous study or treatment plan. The goal was to track any side effects until the drug became commercially available or the program ended. Partic…
Phase 3 • Sponsor: PTC Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New drug aims to help mitochondrial disease patients walk farther
Disease control CompletedThis Phase 3 trial tested a daily injection called elamipretide in 102 adults with primary mitochondrial myopathy, a genetic condition that causes muscle weakness and fatigue. Participants received either the drug or a placebo for 48 weeks. The main goal was to see if the drug co…
Phase 3 • Sponsor: Stealth BioTherapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC