Mitochondrial encephalomyopathy
MONDO:0004675A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. These are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (From Adams et al., Principles of Neurology, 6th ed, pp984-5)
27 clinical trials for this condition and its sub-types, 3 tagged with Mitochondrial encephalomyopathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Mitochondrial encephalomyopathy
-
MELAS syndrome 13 trials · 14 incl. sub-types
10 sub-types
- MELAS syndrome caused by mutation in MTTL1 1 trial
- MELAS syndrome caused by mutation in MTND1 0 trials
- MELAS syndrome caused by mutation in MTND5 0 trials
- MELAS syndrome caused by mutation in MTND6 0 trials
- MELAS syndrome caused by mutation in MTTC 0 trials
- MELAS syndrome caused by mutation in MTTH 0 trials
- MELAS syndrome caused by mutation in MTTK 0 trials
- MELAS syndrome caused by mutation in MTTQ 0 trials
- MELAS syndrome caused by mutation in MTTS1 0 trials
- MELAS syndrome caused by mutation in MTTS2 0 trials
-
MERRF syndrome 5 trials
-
Experimental drug aims to boost energy in rare genetic disorders
Disease control Not yet recruitingThis study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…
Phase 1/2 • Sponsor: George Washington University • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
-
New DNA test could end years of uncertainty for mitochondrial disease patients
Diagnosis Not yet recruitingThis pilot study aims to develop a new digital PCR technique to more accurately diagnose mitochondrial diseases. Researchers will test the method on blood, urine, saliva, and muscle fiber samples from 4 patients. If validated, the technique could be faster and cheaper than curren…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Diagnosis
Last updated Jun 27, 2026 12:04 UTC