Low grade glioma

This study tests a drug called mirdametinib in children, adolescents, and young adults with low-grade glioma, a type of brain tumor. The drug is designed to cross into the brain and block a protein that helps tumors grow. The trial has two phases: Phase 1 finds the safest dose, a…

This study tests whether a targeted drug called selumetinib works as well as standard chemotherapy (carboplatin and vincristine) for children and young adults with a slow-growing brain tumor called low-grade glioma. Participants must be 2 to 21 years old and have a tumor without …

This study looks at whether patients with a certain type of slow-growing brain tumor (low-grade glioma with a BRAF V600 mutation) can safely stop or reduce their dose of two targeted drugs, dabrafenib and trametinib, after 12-24 months of treatment. About 96 participants will eit…

This study is testing proton radiation as a treatment for adults with benign or slow-growing brain tumors. Researchers want to see how well it controls tumor growth and how it affects quality of life and side effects. About 100 participants will receive proton radiation and be fo…

This early-stage trial is testing whether combining a personalized vaccine (PEPIDH1M) with the targeted drug vorasidenib can safely and effectively treat adults with recurrent low-grade gliomas that have a specific IDH1 mutation. Participants receive the drug daily and the vaccin…

This trial tests whether a daily oral drug called trametinib can better control low-grade gliomas in children and young adults compared to standard weekly vinblastine chemotherapy. The study focuses on patients whose tumors do not have certain genetic changes (BRAF V600 mutation)…

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after previous treatment. The study aims to find the highest dose that is safe and …

This pilot study tests whether combining targeted therapy (MAPK inhibitors like trametinib and dabrafenib) with an immunotherapy drug (nivolumab) can safely and effectively treat children with BRAF-altered gliomas, a type of brain tumor. The study includes children with low-grade…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or grown after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor tissue. The main goal is to see how many…

This study is testing whether a newer type of radiation called proton therapy (IMPT) can treat children's brain tumors just as well as standard X-ray therapy (IMRT) but with fewer long-term side effects. About 94 children aged 6 to 16 with low-grade brain tumors will be randomly …

This phase 2 trial tests a vaccine made from glioma antigen peptides combined with an immune booster (Poly-ICLC) in 25 children with recurrent low-grade gliomas that cannot be removed by surgery. The goal is to see if the vaccine can shrink tumors or keep them stable. Children wh…

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor r…

This study tests a radioactive tracer called FET that lights up brain tumor cells on a PET scan. Researchers want to see if FET can better detect whether a brain tumor has come back after treatment, and help tell high-grade from low-grade tumors. About 199 people with known or su…

This early-phase trial at Children's Hospital of Philadelphia is testing whether a radioactive tracer called 18F-Fluciclovine (Axumin) can improve PET-MRI scans for children and young adults with low-grade glioma. About 30 participants will receive the tracer before starting trea…

This study tests a new software called Wave-CAIPI that aims to speed up MRI scans for children with low-grade gliomas. Researchers will compare the fast scans to standard ones to see if they provide the same image quality. The goal is to make imaging quicker and less stressful fo…

This study tests three ways to help adults with low-grade glioma improve memory and attention: an iPad app (ReMind), daily health text messages, and in-person cognitive rehab. About 97 participants will try one of these programs for several weeks, and researchers will track their…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study looks at low-grade gliomas, a slow-growing type of brain tumor, in Argentina. Researchers will review medical records from about 40 patients to find out how common these tumors are and how long people live after diagnosis. The goal is to better understand these tumors …

This study tests a new type of MRI scan that uses a special substance (hyperpolarized 13C pyruvate) to see how brain tumors use energy. Researchers want to know if this scan is safe and can show changes in tumor metabolism over time. About 300 people with low-grade gliomas will b…

This study looks at how people with a slow-growing brain tumor (low-grade glioma) feel during different treatments. Researchers will ask 90 patients about their quality of life, symptoms, and anxiety while they receive either the drug vorasidenib, radiotherapy, or just regular ch…

This study collects tumor samples from 50 adults with low- or high-grade glioma to grow mini-tumors (organoids) in the lab. Researchers will study these organoids to learn why gliomas are so hard to treat and how they spread. The goal is to create personalized 'avatars' for testi…

This study uses advanced MRI scans to better identify parts of brain tumors that are likely to grow back after standard treatment. Researchers will compare these scans with usual methods to see if they can improve radiation planning. About 135 adults with certain brain tumors wil…

This study looks at how electrical pulses used by surgeons during awake brain surgery affect the brain. Researchers will measure brain waves in 12 people with low-grade glioma before and after tumor removal. The goal is to better understand which brain networks are turned off by …