Leber congenital amaurosis
MONDO:0018998Leber congenital amaurosis (LCA) is a retinal dystrophy defined by blindness and responses to electrophysiological stimulation (Ganzfeld electroretinogram (ERG)) below threshold, associated with severe visual impairment within the first year of life.
Also known as: Leber congenital amaurosis, amaurosis congenita of Leber, Leber's congenital tapetoretinal degeneration, Leber's congenital tapetoretinal dysplasia, congenital absence of the rods and cones, congenital retinal blindness
38 clinical trials for this condition and its sub-types, 11 tagged with Leber congenital amaurosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Leber congenital amaurosis
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Leber congenital amaurosis 2 3 trials
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Leber congenital amaurosis 10 2 trials
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Leber congenital amaurosis 5 2 trials
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Leber congenital amaurosis 1 1 trial
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Leber congenital amaurosis 11 0 trials
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Leber congenital amaurosis 12 0 trials
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Leber congenital amaurosis 13 0 trials
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Leber congenital amaurosis 14 0 trials
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Leber congenital amaurosis 15 0 trials
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Leber congenital amaurosis 16 0 trials
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Leber congenital amaurosis 17 0 trials
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Leber congenital amaurosis 18 0 trials
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Leber congenital amaurosis 19 0 trials
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Leber congenital amaurosis 3 0 trials
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Leber congenital amaurosis 4 0 trials
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Leber congenital amaurosis 6 0 trials
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Leber congenital amaurosis 7 0 trials
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Leber congenital amaurosis 8 0 trials
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Leber congenital amaurosis 9 0 trials
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Retinal aplasia 0 trials
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One-Time gene injection aims to rescue sight in rare childhood blindness
Disease control Not yet recruitingThis study tests a gene therapy called OPGx-RDH12 for people with Leber Congenital Amaurosis (LCA) caused by mutations in the RDH12 gene, a rare condition that leads to severe vision loss from a young age. The treatment is given as a single injection under the retina in the worse…
Phase 1/2 • Sponsor: Opus Genetics, Inc • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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New eye scanner could spot hidden signs of blindness
Diagnosis Not yet recruitingThis study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …
Sponsor: IRCCS San Raffaele • Aim: Diagnosis
Last updated Jun 27, 2026 08:07 UTC
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New eye camera could spot retinal disease earlier
Knowledge-focused Not yet recruitingThis study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…
Sponsor: Stuart Terry Eye Associates • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Scientists track eye disease patterns to speed future cures
Knowledge-focused Not yet recruitingThis study looks back at medical records of 200 people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Researchers will analyze vision tests and eye scans to see how these diseases progress and how genetics affect symptoms. The goal is to find be…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC