Latent autoimmune diabetes in adults

Researchers are testing whether a structured primary care program can help adults aged 40 to 90 with higher heart or diabetes risk reach recommended prevention targets. The program trains doctors and nurses, uses routine data to flag at-risk patients before visits, and provides d…

This study tests whether a continuous glucose monitor (CGM) worn on the skin can accurately track blood sugar levels in hospitalized patients with diabetes who have just had major transplant surgery. The CGM measures glucose every 1-5 minutes, and researchers compare its readings…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This early-phase study tests a new type of CAR-T cell therapy in 9 people with autoimmune diseases that have not responded well to standard treatments. The therapy uses specially engineered immune cells to target and attack faulty immune cells. The main goal is to check safety an…

This study tests whether repeated doses of the BCG vaccine (originally for tuberculosis) can help adults with long-standing type 1 diabetes lower their blood sugar levels. About 150 participants receive either BCG or a placebo over 5 years, with follow-up for 10 years. The goal i…

This study tests whether a blood test for NT-proBNP can spot undiagnosed heart failure in 706 people with diabetes who are at high risk. Those with elevated levels get a heart ultrasound and exam. The goal is to see if this screening strategy leads to more early diagnoses and pro…

This study follows 5,000 people with diabetes who use a Dexcom continuous glucose monitoring (CGM) system in their daily routine. Researchers will track how the device performs when used as labeled and ask participants to complete questionnaires over four years. The goal is to un…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study looks at how a measure called the hemoglobin glycation index (HGI) changes over time in 750 adults with diabetes who use continuous glucose monitors. HGI compares lab-measured blood sugar levels with estimated levels from a glucose monitor. Researchers will collect dat…

This registry enrolls up to 1,000 women aged 12–55 with rheumatic or autoimmune diseases who are pregnant or planning pregnancy. Researchers will collect data from medical records and patient surveys to study pregnancy outcomes, disease activity, and medication use. No experiment…

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD) by analyzing blood samples from 25 adults with type 1 diabetes. Researchers will measure changes in specific microRNAs from tiny particles in the blood. No treatment is given; …

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This observational study tracks 300 adults with diabetes who take SGLT-2 inhibitors and are recovering from surgery in the intensive care unit. Researchers want to find out how often a rare type of diabetic ketoacidosis (called euglycemic DKA) occurs after surgery. The goal is to…