Keratoconus

This study tests whether it is safe and possible to perform corneal cross-linking on both eyes on the same day in people with keratoconus, a condition where the cornea thins and bulges. Fifteen participants will receive riboflavin eye drops and UV-A light treatment in both eyes a…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study tests INTACS prescription inserts, small plastic implants placed in the cornea, to reduce astigmatism and improve vision in people with keratoconus. The goal is to help patients who can no longer see well with glasses or contacts and may otherwise need a corneal transp…

This Phase 2 trial tests whether GLK-221 eye drops can safely slow the progression of keratoconus, a condition that thins and bulges the cornea. About 100 adults with keratoconus will use the drops twice daily for several months. The main goal is to see if the drops reduce the st…

This phase 3 trial tests whether a shorter 18-minute ultraviolet (UVA) light exposure works as well as the standard 24-minute exposure during corneal crosslinking for keratoconus and similar conditions. The treatment uses riboflavin (vitamin B2) eye drops followed by UVA light to…

This Phase 3 trial tests a treatment called corneal crosslinking (CXL) for people with Down syndrome who have keratoconus, a condition where the cornea thins and bulges, blurring vision. The procedure uses vitamin B2 eye drops and ultraviolet light to strengthen the cornea. Resea…

This study tests whether combining a laser vision correction (PRK) with corneal cross-linking improves eyesight and corneal shape better than cross-linking alone in people with keratoconus, a condition that thins and bulges the cornea. Fifty adults aged 18-40 with mild to moderat…

This early study tests a tiny, permanent metal mesh (nitinol) implant placed inside the cornea to stabilize the eye and improve vision in people with advanced keratoconus. The trial involves 12 adults who are not candidates for other treatments and are currently recommended for a…

This study tests a new device called the Gebauer Lenticule, a tiny implant made from pig collagen, for people with severe keratoconus or post-LASIK ectasia. The implant is placed inside the cornea to strengthen it and improve stability, potentially delaying or avoiding the need f…

This study tests a device that uses riboflavin (vitamin B2) drops and UV light to stiffen the cornea, the clear front part of the eye. It is for people with keratoconus or similar conditions that cause the cornea to bulge and blur vision. The goal is to see if the treatment safel…

This study tests a laser-guided procedure to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The procedure uses OCT scans to plan a custom laser treatment that smooths the cornea and strengthens it with cross-linking. Researchers aim to se…

This study is testing a new imaging device called a Brillouin microscope, which uses light to measure the stiffness and water content of eye tissues. The goal is to see if this tool can help doctors better understand and diagnose eye conditions like glaucoma, dry eye, and keratoc…

This study is testing a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of 168 volunteers, including healthy people and those with keratoconus or post-LASIK ectasia, t…

This study aims to improve how doctors detect, classify, and treat irregular corneas caused by conditions like keratoconus, dry eye, and corneal scars. Researchers will use a special imaging device called optical coherence tomography (OCT) to get detailed measurements of the corn…

This study compares measurements from two biometers—devices that use light to measure the eye's internal structures—to see if they agree. The measurements are important for calculating the correct lens power before cataract surgery. The study includes people with healthy eyes, ke…

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…

This study follows thousands of people with keratoconus, a condition that makes the cornea thin and bulge. Researchers measure the eye's shape and vision over many years to understand how the disease starts and changes. No new treatments are tested—the goal is simply to learn mor…

This long-term study collects data from over 100 eye clinics in Germany to see how corneal transplant surgeries have changed since 2001. Researchers track the number of surgeries, the types of procedures used, and the reasons people need them. The goal is to understand trends, no…

This study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study involves 135 adults getting a cornea transplant. Surgeons will use a new method to check the health of donor eye tissue before surgery. The goal is to see if this check helps predict how well the transplant will work long-term, reducing the chance of graft failure.

This study is testing whether a special eye scanner (OCT) can help fit scleral contact lenses more accurately than the usual method. Researchers will enroll 258 people with conditions like keratoconus or scarred corneas. Each participant will have lenses fitted both the standard …

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, over two years. Researchers will track changes in vision, corneal shape, and thickness, and analyze tear proteins to better understand how the disease progresses. Some participants will …