Juvenile dermatomyositis
MONDO:0008054Juvenile dermatomyositis (JDM) is the early-onset form of dermatomyositis (DM), a systemic, autoimmune inflammatory muscle disorder, characterized by proximal muscle weakness, evocative skin lesion, and systemic manifestations.
Also known as: childhood dermatomyositis, inflammation of myoseptum, juvenile DM, juvenile dermatomyositis, myoseptum inflammation, myoseptumitis, JDM, JPM
50 clinical trials for this condition and its sub-types, 41 tagged with Juvenile dermatomyositis itself.
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Can a targeted immune drug calm rare muscle inflammation?
Disease control CompletedThis trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …
Phase 2/3 • Sponsor: argenx • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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New drug combo shows promise for rare childhood muscle disease
Disease control CompletedThis study tested the drug baricitinib, given with steroids, in 16 children aged 3-18 with newly diagnosed juvenile dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if baricitinib works better than the standard treatment (methotrexate p…
Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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MRI may replace needle biopsy for muscle disease diagnosis
Diagnosis CompletedThis study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Jun 27, 2026 12:02 UTC
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Two-Minute sweat test could spot hidden nerve damage
Diagnosis CompletedThis study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…
Sponsor: Hôpital Européen Marseille • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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Which exercise focus works best for kids with rheumatic conditions?
Symptom relief CompletedThis study tested two different exercise programs in 28 children and teens with rheumatic diseases like juvenile arthritis and familial Mediterranean fever. One program used external focus (thinking about the movement's effect), the other used internal focus (thinking about the b…
Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Military myositis mystery: could exposures be the trigger?
Knowledge-focused CompletedThis study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…
Sponsor: National Institute of Environmental Health Sciences (NIEHS) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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NIH launches major study to unlock secrets of rare inflammatory diseases
Knowledge-focused CompletedThis study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Coaching eases tough move to adult rheumatology care
Knowledge-focused CompletedThis study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …
Sponsor: McMaster University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC