Isolated spina bifida

This study tests a new way to repair spina bifida before birth using a tiny camera and a patch made from donated human umbilical cord tissue. The patch is placed over the spinal cord to create a watertight seal, which may reduce problems after birth. The trial includes 50 pregnan…

This study tests a liquid medicine called mirabegron in children aged 6 months to 3 years who have bladder problems due to nerve damage (neurogenic detrusor overactivity). The goal is to see if the medicine helps the bladder hold more urine safely, reducing leaks and pressure. Ch…

This study tests two ways to surgically repair spina bifida in the womb using a tiny camera. The goal is to close the spinal defect and reverse brain changes caused by the condition. About 110 pregnant women carrying babies with spina bifida will take part. The two methods are co…

This study tests a minimally invasive fetoscopic surgery to repair spina bifida in unborn babies. The goal is to close the spinal defect and reverse brain herniation while reducing risks like uterine rupture and preterm birth that come with open fetal surgery. Thirty pregnant wom…

This study tests two minimally invasive fetal surgery techniques for repairing neural tube defects (spina bifida) in the womb. One method uses a Durepair patch to reinforce the repair, while the other does not. Researchers aim to see if the patch leads to a thicker repair and few…

This study tests a 6-8 week running program adapted for children with mobility challenges like cerebral palsy. The program uses a special device called a RaceRunner to help kids participate. Researchers will measure endurance, speed, and heart rate to see if the program improves …

This pilot study tests a program called ALIGN, designed to help adults with spina bifida improve how they manage health tasks like coordinating care and handling medications. The program includes six virtual group sessions and one individual session with a clinician. Researchers …

This study tests whether a non-invasive device that delivers pulsed electromagnetic fields can improve bladder function in 40 children aged 4-12 with myelomeningocele (a form of spina bifida). The treatment aims to stimulate nerves controlling the bladder, potentially reducing in…

This study examines whether removing the breathing tube (extubation) in the operating room versus later in the intensive care unit improves outcomes for newborns undergoing surgery for myelomeningocele, a type of spina bifida. Researchers will review records of 60 babies to compa…

This study is creating a new tool for children with spina bifida and their doctors to work together on setting personal goals for managing bladder and bowel leakage. The goal is to improve the child's quality of life by focusing on what matters most to them, rather than just medi…