Intrahepatic cholestasis of pregnancy
MONDO:0100429A cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery.
Also known as: gravidic intrahepatic cholestasis, intrahepatic cholestasis of pregnancy, pregnancy related cholestasis, pregnancy-related cholestasis, recurrent intrahepatic cholestasis of pregnancy, RICP, cholestasis, intrahepatic of pregnancy, familial intrahepatic cholestasis of pregnancy
13 clinical trials for this condition and its sub-types, 6 tagged with Intrahepatic cholestasis of pregnancy itself.
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Sub-types of Intrahepatic cholestasis of pregnancy
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Can an experimental drug ease a pregnancy liver condition?
Symptom relief Not yet recruitingIntrahepatic cholestasis of pregnancy is a liver condition that causes severe itching and can pose risks to both mother and baby. Researchers are testing whether an oral drug called maralixibat is safe and well tolerated in pregnant women with this condition. All 15 participants …
Phase 2 • Sponsor: Mirum Pharmaceuticals, Inc. • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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One shot during c-section may stop unbearable itching for moms with liver condition
Symptom relief Not yet recruitingThis study tests whether giving a single intravenous dose of esketamine during a C-section can reduce the intense itching that often follows surgery in women with intrahepatic cholestasis of pregnancy. 160 women will be randomly assigned to receive either esketamine or a placebo …
Sponsor: Tianjin Medical University General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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New hope for Moms-to-Be: drug targets dangerous pregnancy itch
Symptom relief Not yet recruitingThis early-stage study tests a drug called maralixibat in 28 pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes severe itching and high bile acids. The main goal is to see if the drug is safe and tolerable for both mother and baby. Rese…
Phase 2 • Sponsor: Imperial College London • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC