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Intellectual disability
MONDO:0001071A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group.
Also known as: intellectual disabilities, intellectual disability
174 clinical trials for this condition and its sub-types, 137 tagged with Intellectual disability itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Intellectual disability
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Syndromic intellectual disability 2 trials · 38 incl. sub-types
17 sub-types
- Autosomal dominant syndromic intellectual disability 0 trials · 15 incl. sub-types Sub-types →
- X-linked syndromic intellectual disability 0 trials · 12 incl. sub-types Sub-types →
- Smith-Magenis syndrome 5 trials
- Rubinstein-Taybi syndrome 3 trials Sub-types →
- Autosomal recessive syndromic intellectual disability 0 trials · 1 incl. sub-types Sub-types →
- Dyneinopathy 0 trials · 1 incl. sub-types Sub-types →
- 2p25.3 microduplication syndrome 0 trials
- 3q27.3 microdeletion syndrome 0 trials
- 7p22.1 microduplication syndrome 0 trials
- 9p13 microdeletion syndrome 0 trials
- 9q31.1q31.3 microdeletion syndrome 0 trials
- 9q33.3q34.11 microdeletion syndrome 0 trials
- AHDC1-related intellectual disability - obstructive sleep apnea - mild dysmorphism syndrome 0 trials
- CK syndrome 0 trials
- Aplasia cutis-enamel dysplasia syndrome 0 trials
- Intellectual disability, Buenos-Aires type 0 trials
- Intellectual disability, Wolff type 0 trials
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Intellectual disability, autosomal dominant 0 trials · 23 incl. sub-types
29 sub-types
- Autosomal dominant syndromic intellectual disability 0 trials · 15 incl. sub-types Sub-types →
- Autosomal dominant non-syndromic intellectual disability 0 trials · 8 incl. sub-types Sub-types →
- Intellectual disability, autosomal dominant 5 2 trials
- Intellectual developmental disorder, autosomal dominant 64 0 trials
- Intellectual developmental disorder, autosomal dominant 65 0 trials
- Intellectual developmental disorder, autosomal dominant 66 0 trials
- Intellectual developmental disorder, autosomal dominant 67 0 trials
- Intellectual developmental disorder, autosomal dominant 68 0 trials
- Intellectual developmental disorder, autosomal dominant 69 0 trials
- Intellectual developmental disorder, autosomal dominant 70 0 trials
- Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities 0 trials
- Intellectual developmental disorder, autosomal dominant 72 0 trials
- Intellectual developmental disorder, autosomal dominant 74 0 trials
- Intellectual developmental disorder, autosomal dominant 75 0 trials
- Intellectual developmental disorder, autosomal dominant 76 0 trials
- Intellectual disability, autosomal dominant 1 0 trials
- Intellectual disability, autosomal dominant 10 0 trials
- Intellectual disability, autosomal dominant 11 0 trials
- Intellectual disability, autosomal dominant 2 0 trials
- Intellectual disability, autosomal dominant 24 0 trials
- Intellectual disability, autosomal dominant 3 0 trials
- Intellectual disability, autosomal dominant 38 0 trials
- Intellectual disability, autosomal dominant 39 0 trials
- Intellectual disability, autosomal dominant 4 0 trials
- Intellectual disability, autosomal dominant 40 0 trials
- Intellectual disability, autosomal dominant 42 0 trials
- Intellectual disability, autosomal dominant 6 0 trials
- Intellectual disability, autosomal dominant 9 0 trials
- Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 0 trials
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X-linked intellectual disability 1 trial · 15 incl. sub-types
2 sub-types
- X-linked syndromic intellectual disability 0 trials · 12 incl. sub-types Sub-types →
- Non-syndromic X-linked intellectual disability 0 trials · 3 incl. sub-types Sub-types →
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Non-syndromic intellectual disability 0 trials · 10 incl. sub-types
3 sub-types
- Autosomal dominant non-syndromic intellectual disability 0 trials · 8 incl. sub-types Sub-types →
- Non-syndromic X-linked intellectual disability 0 trials · 3 incl. sub-types Sub-types →
- Autosomal recessive non-syndromic intellectual disability 0 trials Sub-types →
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Intellectual disability, autosomal recessive 0 trials · 1 incl. sub-types
3 sub-types
Most studied deeper sub-types
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Smart inhaler cap aims to bridge asthma care gap for teens with disabilities
Disease control Recruiting nowThis pilot trial tests whether a digital inhaler cap, which gives real-time guidance on inhaler technique, can help adolescents with intellectual and developmental disabilities (IDD) manage their asthma at home. The study will compare active use of the smart inhaler to passive us…
Sponsor: Children's Hospital Los Angeles • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Cooking up a solution: new study tests kitchen skills for weight loss in intellectual disabilities
Disease control Recruiting nowThis study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (18-35) with mild-to-moderate intellectual disabilities lose more weight and keep it off. Over 24 months, 114 participants will either follow a healthy eating plan with c…
Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
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Brain-Training games tested as a tool for intellectual disabilities
Disease control Recruiting nowThis study tests whether playing digital brain games on the MentalUP app can improve visual memory and cognitive skills in young adults (18-35) with mild to moderate intellectual disabilities. Sixty participants will be split into two groups: one plays the games, the other contin…
Sponsor: Koç University • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Gene therapy aims to halt rare childhood paralysis disorder
Disease control Recruiting nowThis trial tests a single injection of MELPIDA, a gene therapy that delivers a working copy of the AP4M1 gene directly into the spinal fluid of children with SPG50. SPG50 is a rare genetic condition that causes muscle stiffness, intellectual disability, and developmental delays. …
Phase 1/2 • Sponsor: Elpida Therapeutics SPC • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New study aims to help people with disabilities suffering from uncontrollable movements
Disease control Recruiting nowThis study tests a drug called deutetrabenazine for tardive dyskinesia (uncontrollable movements) in 25 adults with intellectual/developmental disabilities and psychiatric or behavioral disorders. Participants will take the medication for 24 weeks to see if it reduces movement pr…
Phase 4 • Sponsor: University Hospitals Cleveland Medical Center • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Could a common diabetes drug curb weight gain in people with intellectual disabilities?
Disease control Recruiting nowThis study tests whether metformin, a diabetes drug, can help adults with intellectual disabilities who have gained weight from antipsychotic medications. One hundred participants will receive either metformin or a placebo for 24 weeks, along with lifestyle advice. The goal is to…
Phase 4 • Sponsor: Centre for Addiction and Mental Health • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New exercise program aims to get adults with intellectual disability moving more
Disease control Recruiting nowThis study tests a 16-week inclusive exercise program called PACE for adults with intellectual disability. Participants will attend fitness classes, meet with coaches, and use a web dashboard to set goals. The trial includes 376 people and will measure daily steps and moderate-to…
Sponsor: University of North Carolina, Chapel Hill • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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One-Dose antibiotic could slash ventilator pneumonia deaths in brain injury patients
Prevention Recruiting nowThis study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…
Phase 3 • Sponsor: The George Institute • Aim: Prevention
Last updated Aug 30, 2026 00:00 UTC
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Brain zaps tested to calm emotional storms in autism
Symptom relief Recruiting nowResearchers at Chang Gung Memorial Hospital are testing whether intermittent theta burst stimulation, a non-invasive form of brain stimulation, can help autistic people with minimal verbal ability or intellectual disability regulate their emotions and behavior. The study enrolls …
Sponsor: Chang Gung Memorial Hospital • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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Can a shared framework make disability care more coordinated?
Symptom relief Recruiting nowResearchers are testing whether an interdisciplinary case management approach built on the International Classification of Functioning, Disability and Health (ICF) improves rehabilitation for adults with mild to moderate intellectual disabilities. The trial enrolls 120 adults fro…
Sponsor: The Hong Kong Polytechnic University • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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New therapy aims to tame emotional meltdowns in kids with autism and intellectual disability
Symptom relief Recruiting nowThis study adapts a group therapy program called Regulating Together for children aged 8-12 with autism and intellectual disability who struggle with emotions like irritability and aggression. The therapy uses relaxation, mindfulness, and parent training to help kids regulate the…
Sponsor: Children's Mercy Hospital Kansas City • Aim: Symptom relief
Last updated Sep 05, 2026 00:00 UTC
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Pre-dental video call may ease clinic visits for patients with special needs
Symptom relief Recruiting nowThis study tests whether a short telehealth interview 3-7 days before a dental checkup helps patients with intellectual or developmental disabilities (IDD) have a smoother visit. About 50 youth with IDD and their caregivers will be randomly assigned to receive the telehealth call…
Sponsor: Boston University • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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New drug trial aims to ease fragile x symptoms in men
Symptom relief Recruiting nowThis study tests a new medicine called CTH120 in 30 adult men with Fragile X syndrome. The main goal is to see if the drug is safe and tolerable, while also checking if it helps improve symptoms. Participants will receive the drug and be monitored closely for side effects and cha…
Phase 2 • Sponsor: Connecta Therapeutics, S.L. • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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Mobile pain team brings relief to kids with intellectual disabilities
Symptom relief Recruiting nowThis study tests a mobile team of pain specialists who visit children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities. The team works with families and caregivers to assess and manage pain in the patient's usual …
Sponsor: University Hospital, Brest • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Scientists hunt for hidden genes behind rare disorders
Knowledge-focused Recruiting nowThis study aims to identify the genetic causes of rare, undiagnosed disorders by using genome sequencing. Researchers will analyze the DNA of up to 2,000 participants, including affected individuals and their family members. The goal is to discover new disease-causing genes and i…
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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Scientists probe pain in people with intellectual disability
Knowledge-focused Recruiting nowThis study compares brain responses to heat, cold, brushing, and mild electric shocks in people with and without intellectual disability. Researchers use brain scans and heart rate monitors to measure pain. The goal is to better understand how pain is felt in this group, especial…
Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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New study aims to predict falls in people with intellectual disabilities
Knowledge-focused Recruiting nowThis study will follow 900 Spanish adults with intellectual disabilities for one year to understand why they fall. Researchers will check medical records, balance, and walking ability. The goal is to create a tool that can predict who is at risk of falling, so caregivers can take…
Sponsor: Fundación Hospitalarias Betanzos • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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NIH launches study to unravel mysteries of rare CDG diseases
Knowledge-focused Recruiting nowThis study from the National Human Genome Research Institute aims to better understand Congenital Disorders of Glycosylation (CDG), a group of rare genetic conditions that affect how the body attaches sugars to proteins and fats. Researchers will examine up to 200 participants, i…
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Can genes explain brain malformations?
Knowledge-focused Recruiting nowThis study aims to understand the genetic causes of brain development disorders, including Aicardi syndrome, polymicrogyria, and Dandy-Walker malformation. Researchers will analyze genetic data from 2000 participants with these conditions, all confirmed by MRI. The goal is to use…
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Aug 19, 2026 00:00 UTC
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Scientists to unravel trust in intellectual disability
Knowledge-focused Recruiting nowThis study looks at how people with Down syndrome and Fragile X syndrome decide who to trust. Researchers will use eye-tracking and behavioral tasks to measure how participants read faces, behaviors, and detect deception. The goal is to understand the brain mechanisms behind trus…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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Massive global registry aims to unlock secrets of rett syndrome
Knowledge-focused Recruiting nowThis study creates a large registry of people with Rett syndrome, a rare genetic disorder that causes severe intellectual and physical disabilities. Researchers will collect information from doctors and caregivers to understand how the disease progresses over time. The goal is to…
Sponsor: International Rett Syndrome Foundation • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Scientists launch study to unravel rare MEHMO syndrome
Knowledge-focused Recruiting nowThis observational study follows 150 people with MEHMO syndrome or related conditions to better understand how the disease progresses. Researchers will collect medical history, imaging, and lab samples to find biological markers that could help monitor the disease. No treatment i…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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New study aims to uncover hidden bathroom struggles in kids with intellectual disabilities
Knowledge-focused Recruiting nowThis study looks at bladder and bowel problems in children aged 5 to 12 with intellectual disabilities and compares them to typically developing children. Researchers want to understand how these issues affect the child's daily activities and family quality of life. The goal is t…
Sponsor: Abant Izzet Baysal University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Hidden disabilities: new study probes neurodevelopmental disorders in the homeless
Knowledge-focused Recruiting nowThis pilot study will screen 150 homeless adults in French shelters for autism, ADHD, and intellectual disability using interviews and questionnaires. The goal is to find out how many have these conditions, which may have contributed to their homelessness. Results could help tail…
Sponsor: Hôpital le Vinatier • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Scientists study rare gene to unravel autism and speech problems
Knowledge-focused Recruiting nowThis study looks at people who have changes in a gene called FOXP1, which can cause developmental delays, speech problems, and autism-like traits. Researchers will use interviews, play-based assessments, and genetic tests to better understand these conditions. The goal is to lear…
Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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New RNA test could end diagnostic odyssey for rare disease patients
Knowledge-focused Recruiting nowThis study tests whether analyzing RNA from blood and skin samples can find hidden genetic causes in people with rare diseases like intellectual disability. Researchers will compare results from both tissues to see which works best. The goal is to reduce the years of uncertainty …
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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LEGO robots may unlock play for children with disabilities
Knowledge-focused Recruiting nowThis study looks at how technology, like LEGO robots, can help children with physical disabilities play. Researchers will ask parents and kids about what helps or hinders play, then let children play with robots or conventional toys. The goal is to create a complete model of play…
Sponsor: University of Manitoba • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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New study aims to catch vision issues in adults with intellectual disability
Knowledge-focused Recruiting nowThis study aims to develop and test a simple scale that caregivers can use to detect common eye disorders in adults with intellectual disability. Researchers will collect data from 1,400 participants, including socioeconomic information, daily living skills, and eye exam results.…
Sponsor: National Taiwan University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Can tailored therapy help teens with behavioral issues and intellectual disabilities?
Knowledge-focused Recruiting nowThis study looks at whether a special version of multisystemic therapy (MST-ID) works better than standard therapy for teenagers (ages 10-19) with severe behavioral problems who come from families with intellectual disabilities. About 470 teens and their families will take part, …
Sponsor: De Viersprong • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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New study aims to decode emotional challenges in intellectual disability
Knowledge-focused Recruiting nowThis study looks at how adults with intellectual developmental disorder (IDD) understand emotions, compared to people without IDD. Researchers will test 60 adults using tasks that involve recognizing facial expressions, emotions in context, and vocal tones. The goal is to find sp…
Sponsor: Hôpital le Vinatier • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Brain scans could unlock secrets of childhood disorders
Knowledge-focused Recruiting nowThis study uses magnetoencephalography (MEG), a non-invasive brain scan, to compare brain signals in 1,500 children with neurodevelopmental disorders (like epilepsy, autism, ADHD) and healthy children. The goal is to improve diagnosis and understanding of these conditions. No tre…
Sponsor: Children's Hospital of Fudan University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Families help unlock genetic secrets of intellectual disability and autism
Knowledge-focused Recruiting nowThis study aims to build a database of genetic information from 1,000 people with intellectual disabilities or autism spectrum disorders of known genetic cause. Families will answer online questionnaires to share clinical details, helping researchers understand how different gene…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Could letting people choose how they communicate reduce challenging behavior?
Knowledge-focused Recruiting nowThis study looks at whether using a preferred communication method (like a touch talker or picture cards) helps people with intellectual or developmental disabilities maintain positive behavior changes and avoid relapse. Researchers will compare two groups: one starting with a pr…
Sponsor: Joel E. Ringdahl • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Massive study tracks 1,000 people with rare genetic brain conditions to map symptoms
Knowledge-focused Recruiting nowThis study follows 1,000 people who have certain genetic changes (hnRNP and others) that may cause developmental delays, autism, seizures, or muscle problems. Researchers collect medical records, school reports, and questionnaires to see how these gene variants affect behavior, t…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
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Can a light box lift depression in people with intellectual disabilities?
Knowledge-focused Recruiting nowThis study looks at whether bright light therapy can help reduce depressive symptoms in adults with intellectual disabilities. Researchers will see how acceptable and practical this treatment is in two care organizations. About 105 participants, including staff and patients, will…
Sponsor: Erasmus Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC