Infectious otitis media
MONDO:0024330Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space.
Also known as: otitis media, AOM, acute otitis Media, infectious otitis Media, middle Ear infection
30 clinical trials for this condition and its sub-types, 24 tagged with Infectious otitis media itself.
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New vaccine shows promise against childhood ear infections
Vaccine CompletedThis study tested a new vaccine called V114 in over 7,000 healthy infants to see if it could prevent ear infections caused by certain pneumococcal bacteria. The vaccine was given alongside routine childhood shots. Researchers tracked how many babies got vaccine-type ear infection…
Phase 3 • Sponsor: Merck Sharp & Dohme LLC • Aim: Vaccine
Last updated Jun 27, 2026 08:12 UTC
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New pneumonia vaccine passes first safety check in small human trial
Vaccine CompletedThis early-stage trial tested whether a new whole-cell pneumonia vaccine is safe for people. Thirty healthy adults received either the vaccine or a placebo and were monitored for 30 days. The main goal was to check for side effects like pain, fever, or headache. This study does n…
Phase 1 • Sponsor: Serum Life Science Europe GmbH • Aim: Vaccine
Last updated Jun 27, 2026 07:55 UTC
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Can a probiotic shield kids from antibiotic side effects?
Disease control CompletedThis study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…
Phase 4 • Sponsor: Eskisehir Osmangazi University • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Smart reports guide doctors to better antibiotic choices
Knowledge-focused CompletedThis study tested whether giving doctors automated reports on their antibiotic prescribing habits could improve how often they follow official guidelines. Researchers looked at over 26,000 patients with pneumonia, ear infections, or sore throat. They compared antibiotic use befor…
Sponsor: Children's Hospital of Philadelphia • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC